Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epiblast populations

Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epiblast populations

Abstract Stem cells hold promise in regenerative medicine as they have the potential to differentiate into a variety of specialized cell types. However, mechanisms underlying stem cell potency and lineage acquisition remain elusive. Epigenetic modifications and genome accessibility prime cellular fe...

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Main Authors: Niels Alvaro Menezes, Kathryn Johanna Peterson, Xiaogang Guo, Veronica Castiglioni, Adrija Kalvisa, Katarzyna Filimonow, Karen Schachter, Christina Maria Schuh, Athanasios Pasias, Luca Mariani, Joshua Mark Brickman, Jakub Sedzinski, Elisabetta Ferretti
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60348-6
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