ALDH2 mediates the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on improving cardiac remodeling

ALDH2 mediates the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on improving cardiac remodeling

Abstract Background Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are now recommended for patients with heart failure, but the mechanisms that underlie the protective role of SGLT2i in cardiac remodeling remain unclear. Aldehyde dehydrogenase 2 (ALDH2) effectively prevents cardiac remodeling. H...

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Bibliographic Details
Main Authors: Han Liu, Bingchen Jiang, Rui Hua, Xuehao Liu, Bao Qiao, Xiangxin Zhang, Xilong Liu, Wenjun Wang, Qiuhuan Yuan, Bailu Wang, Shujian Wei, Yuguo Chen
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Cardiovascular Diabetology
Subjects:
Cardiac remodeling
Sodium-glucose cotransporter-2 inhibitors
Aldehyde dehydrogenase 2
Sodium/proton exchanger 1
Methylation
Online Access:https://doi.org/10.1186/s12933-024-02477-8
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