The Genetic and Epigenetic Arms of Human Ageing and Longevity
This proposed review aims to shed light on the major genetic and epigenetic contributions to the ageing process and longevity of individuals. In this context, we summarize the state of knowledge on the most important longevity and ageing genetic variants, and their interactions with the environment,...
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| Format: | Article |
| Language: | English |
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2025-01-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/14/1/92 |
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| author | Elena Ciaglia Francesco Montella Valentina Lopardo Cristina Basile Roberta Maria Esposito Clara Maglio Roberta Longo Anna Maciag Annibale Alessandro Puca |
| author_facet | Elena Ciaglia Francesco Montella Valentina Lopardo Cristina Basile Roberta Maria Esposito Clara Maglio Roberta Longo Anna Maciag Annibale Alessandro Puca |
| author_sort | Elena Ciaglia |
| collection | DOAJ |
| description | This proposed review aims to shed light on the major genetic and epigenetic contributions to the ageing process and longevity of individuals. In this context, we summarize the state of knowledge on the most important longevity and ageing genetic variants, and their interactions with the environment, in achieving a healthy lifespan. We also explore the contribution of lifestyle and the influence of non-heritable environmental factors on ageing (i.e., epigenetics). Accordingly, we discuss the role of inflammageing as one of the major targets to overcome morbidity and mortality in older people for the maintenance of healthy ageing. This more integrated view of longevity will display not only the underlying mechanisms at play but also invites the reader to rethink both our ageing process and our attitudes toward age. |
| format | Article |
| id | doaj-art-53de81ede39f42b0a9c3cf30c7222cc2 |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-53de81ede39f42b0a9c3cf30c7222cc22025-01-24T13:23:37ZengMDPI AGBiology2079-77372025-01-011419210.3390/biology14010092The Genetic and Epigenetic Arms of Human Ageing and LongevityElena Ciaglia0Francesco Montella1Valentina Lopardo2Cristina Basile3Roberta Maria Esposito4Clara Maglio5Roberta Longo6Anna Maciag7Annibale Alessandro Puca8Molecular and Clinical Pathophysiology Lab, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, ItalyMolecular and Clinical Pathophysiology Lab, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, ItalyMolecular and Clinical Pathophysiology Lab, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, ItalyMolecular and Clinical Pathophysiology Lab, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, ItalyMolecular and Clinical Pathophysiology Lab, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, ItalyMolecular and Clinical Pathophysiology Lab, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, ItalyMolecular and Clinical Pathophysiology Lab, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, ItalyCardiovascular Research Unit, IRCCS MultiMedica, 20138 Milan, ItalyMolecular and Clinical Pathophysiology Lab, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, ItalyThis proposed review aims to shed light on the major genetic and epigenetic contributions to the ageing process and longevity of individuals. In this context, we summarize the state of knowledge on the most important longevity and ageing genetic variants, and their interactions with the environment, in achieving a healthy lifespan. We also explore the contribution of lifestyle and the influence of non-heritable environmental factors on ageing (i.e., epigenetics). Accordingly, we discuss the role of inflammageing as one of the major targets to overcome morbidity and mortality in older people for the maintenance of healthy ageing. This more integrated view of longevity will display not only the underlying mechanisms at play but also invites the reader to rethink both our ageing process and our attitudes toward age.https://www.mdpi.com/2079-7737/14/1/92prolonged lifespangenesepigenetic changes |
| spellingShingle | Elena Ciaglia Francesco Montella Valentina Lopardo Cristina Basile Roberta Maria Esposito Clara Maglio Roberta Longo Anna Maciag Annibale Alessandro Puca The Genetic and Epigenetic Arms of Human Ageing and Longevity Biology prolonged lifespan genes epigenetic changes |
| title | The Genetic and Epigenetic Arms of Human Ageing and Longevity |
| title_full | The Genetic and Epigenetic Arms of Human Ageing and Longevity |
| title_fullStr | The Genetic and Epigenetic Arms of Human Ageing and Longevity |
| title_full_unstemmed | The Genetic and Epigenetic Arms of Human Ageing and Longevity |
| title_short | The Genetic and Epigenetic Arms of Human Ageing and Longevity |
| title_sort | genetic and epigenetic arms of human ageing and longevity |
| topic | prolonged lifespan genes epigenetic changes |
| url | https://www.mdpi.com/2079-7737/14/1/92 |
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