Isoleucyl-tRNA synthetase 2 promotes pancreatic ductal adenocarcinoma proliferation and metastasis by stabilizing β-catenin

Isoleucyl-tRNA synthetase 2 promotes pancreatic ductal adenocarcinoma proliferation and metastasis by stabilizing β-catenin

Isoleucyl-tRNA synthetase 2 (IARS2), originally regarded as an enzyme ligating isoleucine to the corresponding tRNA, has been identified as an oncogene recently. However, its function in pancreatic ductal adenocarcinoma (PDAC) remains to be discovered. Here we explored the biological role of IARS2 i...

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Bibliographic Details
Main Authors: Yixun Jin, Xinyang Huang, Zhuoxin Wang, Berik Kouken, Qi Wang, Lifu Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-05-01
Series:Genes and Diseases
Subjects:
Aminoacyl-tRNA synthetases
Isoleucyl-tRNA synthetase 2
Pancreatic ductal adenocarcinoma
WNT signaling pathway
β-Catenin
Online Access:http://www.sciencedirect.com/science/article/pii/S235230422400179X
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