Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction.
The host lymphatic network represents an important conduit for pathogen dissemination. Indeed, the lethal human pathogen group A streptococcus has a predilection to induce pathology in the lymphatic system and draining lymph nodes, however the underlying basis and subsequent consequences for disease...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-09-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1005137 |
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| _version_ | 1849332475637006336 |
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| author | Nicola N Lynskey Suneale Banerji Louise A Johnson Kayla A Holder Mark Reglinski Peter A C Wing David Rigby David G Jackson Shiranee Sriskandan |
| author_facet | Nicola N Lynskey Suneale Banerji Louise A Johnson Kayla A Holder Mark Reglinski Peter A C Wing David Rigby David G Jackson Shiranee Sriskandan |
| author_sort | Nicola N Lynskey |
| collection | DOAJ |
| description | The host lymphatic network represents an important conduit for pathogen dissemination. Indeed, the lethal human pathogen group A streptococcus has a predilection to induce pathology in the lymphatic system and draining lymph nodes, however the underlying basis and subsequent consequences for disease outcome are currently unknown. Here we report that the hyaluronan capsule of group A streptococci is a crucial virulence determinant for lymphatic tropism in vivo, and further, we identify the lymphatic vessel endothelial receptor-1 as the critical host receptor for capsular hyaluronan in the lymphatic system. Interference with this interaction in vivo impeded bacterial dissemination to local draining lymph nodes and, in the case of a hyper-encapsulated M18 strain, redirected streptococcal entry into the blood circulation, suggesting a pivotal role in the manifestation of streptococcal infections. Our results reveal a novel function for bacterial capsular polysaccharide in directing lymphatic tropism, with potential implications for disease pathology. |
| format | Article |
| id | doaj-art-53dd3fe8d8ca4781884062489bb9ec8c |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-53dd3fe8d8ca4781884062489bb9ec8c2025-08-20T03:46:12ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742015-09-01119e100513710.1371/journal.ppat.1005137Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction.Nicola N LynskeySuneale BanerjiLouise A JohnsonKayla A HolderMark ReglinskiPeter A C WingDavid RigbyDavid G JacksonShiranee SriskandanThe host lymphatic network represents an important conduit for pathogen dissemination. Indeed, the lethal human pathogen group A streptococcus has a predilection to induce pathology in the lymphatic system and draining lymph nodes, however the underlying basis and subsequent consequences for disease outcome are currently unknown. Here we report that the hyaluronan capsule of group A streptococci is a crucial virulence determinant for lymphatic tropism in vivo, and further, we identify the lymphatic vessel endothelial receptor-1 as the critical host receptor for capsular hyaluronan in the lymphatic system. Interference with this interaction in vivo impeded bacterial dissemination to local draining lymph nodes and, in the case of a hyper-encapsulated M18 strain, redirected streptococcal entry into the blood circulation, suggesting a pivotal role in the manifestation of streptococcal infections. Our results reveal a novel function for bacterial capsular polysaccharide in directing lymphatic tropism, with potential implications for disease pathology.https://doi.org/10.1371/journal.ppat.1005137 |
| spellingShingle | Nicola N Lynskey Suneale Banerji Louise A Johnson Kayla A Holder Mark Reglinski Peter A C Wing David Rigby David G Jackson Shiranee Sriskandan Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction. PLoS Pathogens |
| title | Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction. |
| title_full | Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction. |
| title_fullStr | Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction. |
| title_full_unstemmed | Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction. |
| title_short | Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction. |
| title_sort | rapid lymphatic dissemination of encapsulated group a streptococci via lymphatic vessel endothelial receptor 1 interaction |
| url | https://doi.org/10.1371/journal.ppat.1005137 |
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