Effect of sodium butyrate on diet-induced obesity in the Sprague-Dawley rat
Obesity has been reported as an increasingly prevalent and highly heritable health problem leading to increased risks for several common diseases. Human obesity can be induced by genetic factors such as loss-of-function mutations in individual genes. The products of these genes are essential for nor...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhejiang University Press
2015-03-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
| Subjects: | |
| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2014.09.192 |
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| Summary: | Obesity has been reported as an increasingly prevalent and highly heritable health problem leading to increased risks for several common diseases. Human obesity can be induced by genetic factors such as loss-of-function mutations in individual genes. The products of these genes are essential for normal body mass regulation in both laboratory animals and humans. Nevertheless, the role of gene-environment interactions in the etiology of obesity cannot be ignored. Diet is a major factor of our current obesogenic environment, and the interests have been aroused in rodent models of diet-induced obesity (DIO) . The SD (Sprague-Dawley) rat model of DIO was been reported to exhibit a clear segregation into susceptible and resistant subpopulations shortly after being transferred to a high energy diet.We established the obesity-susceptible (OS) and obesity-resistant (OR) rat model and examined the effect of butyric acid, a short chain fatty acid formed by fermentation in the large intestine, in the regulation of obesity in mice fed a high-fat diet. Male SD rats were divided into OS rats and OR rats after being fed with high fat diet for three weeks. Then both of them were fed with high fat diet for another 12 weeks. Measurements of body mass, body length, Lee's index, and body mass index (BMI) were performed. After the rats were sacrificed, body fat content, serum total cholesterol (TC) , triglyceride (TG) , high density lipoprotein (HDL) , low density lipoprotein (LDL) and serum leptin were measured.The results showed that there were significant differences in body mass, BMI, body fat content, TC, TG, LDL and serum leptin between OS rats and control rats. But there were no significant differences between OR rats and control rats. In the OS rats, sodium butyrate was administrated in the high-fat diet at the concentration of 8 mmol/L for 16 weeks. Body mass, body length, Lee's index, BMI, body fat content, TC, TG, HDL, LDL and serum leptin were investigated both in obesity intervention with sodium butyrate (OI) group and obesity control (OC) group. The values of body mass, BMI, body fat content, TC, TG, LDL and serum leptin for OI rats were significantly lower than OC rats. But there were no significant differences between OC rats and normal control rats.In conclusion, the supplementation of sodium butyrate in the high-fat diet prevents the development of obesity in the obesity-susceptible SD rat. |
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| ISSN: | 1008-9209 2097-5155 |