Tofacitinib downregulates JAK1 and JAK3 on human intestinal monocytes and macrophages without affecting dendritic cells phenotype or function

Tofacitinib downregulates JAK1 and JAK3 on human intestinal monocytes and macrophages without affecting dendritic cells phenotype or function

Background: Ulcerative colitis (UC) is an inflammatory disorder of the gastrointestinal tract. Although Tofacitinib, which inhibits the JAK1 and JAK3 signalling pathway, is approved to treat patients with UC, its specific mechanism of action remain elusive. Given the central role that conventional d...

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Bibliographic Details
Main Authors: Elisa Arribas-Rodríguez, Ángel De Prado, Beatriz de Andrés, Benito Velayos, Jesús Barrio, Alejandro Romero, Francisco Javier García-Alonso, Álvaro Martín-Muñoz, José A. Garrote, Eduardo Arranz, Luis Fernández-Salazar, David Bernardo
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Translational Autoimmunity
Subjects:
Tofacitinib
Intestine
Ulcerative colitis
Dendritic cells
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909025000061
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