LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease

LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease

Abstract Mitochondria comprise the central metabolic hub of cells and their imbalance plays a pathogenic role in chronic kidney disease (CKD). Here, we studied Lon protease 1 (LONP1), a major mitochondrial protease, as its role in CKD pathogenesis is unclear. LONP1 expression was decreased in human...

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Bibliographic Details
Main Authors: Mi Bai, Mengqiu Wu, Mingzhu Jiang, Jia He, Xu Deng, Shuang Xu, Jiaojiao Fan, Mengqiu Miao, Ting Wang, Yuting Li, Xiaowen Yu, Lin Wang, Yue Zhang, Songming Huang, Li Yang, Zhanjun Jia, Aihua Zhang
Format: Article
Language:English
Published: Springer Nature 2023-01-01
Series:EMBO Molecular Medicine
Subjects:
chronic kidney disease
HMGCS2
LONP1
mitochondrial dysfunction
Online Access:https://doi.org/10.15252/emmm.202216581
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