Association between a specific monocyte subset and heart failure with preserved ejection fraction in patients with uremia
Aim: This study aimed to establish a model based on gene expression in peripheral blood mononuclear cells (PBMCs) for predicting the incidence of heart failure with preserved ejection fraction (HFpEF) in patients with end-stage renal disease (ESRD). Methods: PBMCs were isolated from patients with st...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2025-01-01
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| Series: | Exploration of Cardiology |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A101247/101247.pdf |
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| author | Xinrui Wang Minghui Song Lu Ma Yang Yang |
| author_facet | Xinrui Wang Minghui Song Lu Ma Yang Yang |
| author_sort | Xinrui Wang |
| collection | DOAJ |
| description | Aim: This study aimed to establish a model based on gene expression in peripheral blood mononuclear cells (PBMCs) for predicting the incidence of heart failure with preserved ejection fraction (HFpEF) in patients with end-stage renal disease (ESRD). Methods: PBMCs were isolated from patients with stage 2–3 chronic kidney disease, ESRD, ESRD with HFpEF, and ESRD with heart failure with reduced ejection fraction (HFrEF). Differences in the expression of differentially expressed genes in PBMCs among different groups were compared using microarray. Results: In total, 43 differentially expressed genes were specifically identified in patients with ESRD with HFpEF. The expression of four genes encoding MMP7, S100A8, CXCR3, and CD163 was significantly upregulated. Hence, it played a role in the development of HFpEF. Based on these findings, a nomogram was established using data from the database including 343 patients with ESRD. The receiver operating characteristic curve, calibration curve, model consistency index, and decision curve analyses showed that the nomogram had a good predictive performance for predicting HFpEF. Conclusions: Specific gene detections can be an important early warning indicator and guide physicians in evaluating the risk of HFpEF in ESRD. |
| format | Article |
| id | doaj-art-53d1b56cf4704f39b594e9d80f9005a0 |
| institution | Kabale University |
| issn | 2994-5526 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Cardiology |
| spelling | doaj-art-53d1b56cf4704f39b594e9d80f9005a02025-08-20T03:50:32ZengOpen Exploration Publishing Inc.Exploration of Cardiology2994-55262025-01-01310124710.37349/ec.2025.101247Association between a specific monocyte subset and heart failure with preserved ejection fraction in patients with uremiaXinrui Wang0Minghui Song1Lu Ma2Yang Yang3Laboratory Department, Centre for Disease Prevention and Control of Chang’an District, Shijiazhuang 050000, Hebei, ChinaClinical Laboratory, Hainan Hospital of General Hospital of Chinese People’s Liberation Army, Sanya 572013, Hainan, ChinaDepartment of Nephrology, Beidaihe Rehabilitation and Recuperation Center of the Chinese People’s Liberation Army, Qinhuangdao 066100, Hebei, ChinaDepartment of Nephrology, The 981th Hospital of Joint Logistic Support Force, Chengde 067000, Hebei, ChinaAim: This study aimed to establish a model based on gene expression in peripheral blood mononuclear cells (PBMCs) for predicting the incidence of heart failure with preserved ejection fraction (HFpEF) in patients with end-stage renal disease (ESRD). Methods: PBMCs were isolated from patients with stage 2–3 chronic kidney disease, ESRD, ESRD with HFpEF, and ESRD with heart failure with reduced ejection fraction (HFrEF). Differences in the expression of differentially expressed genes in PBMCs among different groups were compared using microarray. Results: In total, 43 differentially expressed genes were specifically identified in patients with ESRD with HFpEF. The expression of four genes encoding MMP7, S100A8, CXCR3, and CD163 was significantly upregulated. Hence, it played a role in the development of HFpEF. Based on these findings, a nomogram was established using data from the database including 343 patients with ESRD. The receiver operating characteristic curve, calibration curve, model consistency index, and decision curve analyses showed that the nomogram had a good predictive performance for predicting HFpEF. Conclusions: Specific gene detections can be an important early warning indicator and guide physicians in evaluating the risk of HFpEF in ESRD.https://www.explorationpub.com/uploads/Article/A101247/101247.pdfheart failurechronic kidney diseasemonocytemacrophage activationnomogram |
| spellingShingle | Xinrui Wang Minghui Song Lu Ma Yang Yang Association between a specific monocyte subset and heart failure with preserved ejection fraction in patients with uremia Exploration of Cardiology heart failure chronic kidney disease monocyte macrophage activation nomogram |
| title | Association between a specific monocyte subset and heart failure with preserved ejection fraction in patients with uremia |
| title_full | Association between a specific monocyte subset and heart failure with preserved ejection fraction in patients with uremia |
| title_fullStr | Association between a specific monocyte subset and heart failure with preserved ejection fraction in patients with uremia |
| title_full_unstemmed | Association between a specific monocyte subset and heart failure with preserved ejection fraction in patients with uremia |
| title_short | Association between a specific monocyte subset and heart failure with preserved ejection fraction in patients with uremia |
| title_sort | association between a specific monocyte subset and heart failure with preserved ejection fraction in patients with uremia |
| topic | heart failure chronic kidney disease monocyte macrophage activation nomogram |
| url | https://www.explorationpub.com/uploads/Article/A101247/101247.pdf |
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