Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino rats
The purpose of this study is to evaluate the impacts of apricot kernels and caffeine on blood glucose, lipid profile, insulin secretion, and antioxidant effect in diabetic rats. Forty adult male albino rats were divided into five groups: normal control, diabetic control, diabetic rats treated with a...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1358177/full |
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| author | Ahmed El Sayed Nour El-Deen Ahmed El Sayed Nour El-Deen Ahmad Mohamad Taha Ahmad Mohamad Taha Almoatazbellah Elsayed Almoatazbellah Elsayed Ahmed Noaman Ali Ahmed Noaman Ali Reda Samir Taha Reda Samir Taha |
| author_facet | Ahmed El Sayed Nour El-Deen Ahmed El Sayed Nour El-Deen Ahmad Mohamad Taha Ahmad Mohamad Taha Almoatazbellah Elsayed Almoatazbellah Elsayed Ahmed Noaman Ali Ahmed Noaman Ali Reda Samir Taha Reda Samir Taha |
| author_sort | Ahmed El Sayed Nour El-Deen |
| collection | DOAJ |
| description | The purpose of this study is to evaluate the impacts of apricot kernels and caffeine on blood glucose, lipid profile, insulin secretion, and antioxidant effect in diabetic rats. Forty adult male albino rats were divided into five groups: normal control, diabetic control, diabetic rats treated with apricot kernels, diabetic rats treated with caffeine, and diabetic rats treated with apricot kernels plus caffeine. Fasting samples were collected at the end of the study for analysis, and pieces of liver and pancreatic tissues were removed for histological analysis. There was a significant decrease in blood glucose, glycated hemoglobin, body weight, total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) levels and a significant increase in insulin and high-density lipoprotein cholesterol (HDL-C) levels in the kernel and caffeine-treated groups. However, there was little histological alteration in the liver or pancreas, and no significant differences were observed in the histological findings between groups. Overall, it can be concluded that apricot kernel and caffeine had a positive effect in decreasing blood glucose and harmful lipid profile and that caffeine had a synergistic effect on the apricot kernel. |
| format | Article |
| id | doaj-art-53cda02ca7e3405a9b0a440f7c11c025 |
| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-53cda02ca7e3405a9b0a440f7c11c0252024-11-14T04:49:42ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-11-011510.3389/fphys.2024.13581771358177Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino ratsAhmed El Sayed Nour El-Deen0Ahmed El Sayed Nour El-Deen1Ahmad Mohamad Taha2Ahmad Mohamad Taha3Almoatazbellah Elsayed4Almoatazbellah Elsayed5Ahmed Noaman Ali6Ahmed Noaman Ali7Reda Samir Taha8Reda Samir Taha9Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, JordanDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptDepartment of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, JordanDepartment of Physiology, Faculty of Medicine, Port Said University, Port Said, EgyptDepartment of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, JordanDepartment of Pathology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptDepartment of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, JordanDepartment of Oral Pathology, Faculty of Dentistry, Tanta University, Tanta, EgyptDepartment of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, JordanDepartment of Anatomy, Faculty of Medicine in Damietta, Al-Azhar University, Assiut, EgyptThe purpose of this study is to evaluate the impacts of apricot kernels and caffeine on blood glucose, lipid profile, insulin secretion, and antioxidant effect in diabetic rats. Forty adult male albino rats were divided into five groups: normal control, diabetic control, diabetic rats treated with apricot kernels, diabetic rats treated with caffeine, and diabetic rats treated with apricot kernels plus caffeine. Fasting samples were collected at the end of the study for analysis, and pieces of liver and pancreatic tissues were removed for histological analysis. There was a significant decrease in blood glucose, glycated hemoglobin, body weight, total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) levels and a significant increase in insulin and high-density lipoprotein cholesterol (HDL-C) levels in the kernel and caffeine-treated groups. However, there was little histological alteration in the liver or pancreas, and no significant differences were observed in the histological findings between groups. Overall, it can be concluded that apricot kernel and caffeine had a positive effect in decreasing blood glucose and harmful lipid profile and that caffeine had a synergistic effect on the apricot kernel.https://www.frontiersin.org/articles/10.3389/fphys.2024.1358177/fulltype 2 diabetes mellitusapricot kernelscaffeineAntioxidantnutritarian |
| spellingShingle | Ahmed El Sayed Nour El-Deen Ahmed El Sayed Nour El-Deen Ahmad Mohamad Taha Ahmad Mohamad Taha Almoatazbellah Elsayed Almoatazbellah Elsayed Ahmed Noaman Ali Ahmed Noaman Ali Reda Samir Taha Reda Samir Taha Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino rats Frontiers in Physiology type 2 diabetes mellitus apricot kernels caffeine Antioxidant nutritarian |
| title | Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino rats |
| title_full | Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino rats |
| title_fullStr | Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino rats |
| title_full_unstemmed | Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino rats |
| title_short | Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino rats |
| title_sort | impact of co administration of apricot kernels and caffeine on adult male diabetic albino rats |
| topic | type 2 diabetes mellitus apricot kernels caffeine Antioxidant nutritarian |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1358177/full |
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