The Impact of “Omic” and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents
Understanding the interactions between host and pathogen is important for the development and assessment of medical countermeasures to infectious agents, including potential biodefence pathogens such as Bacillus anthracis, Ebola virus, and Francisella tularensis. This review focuses on technological...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/237043 |
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| author | Julia A. Tree Helen Flick-Smith Michael J. Elmore Caroline A. Rowland |
| author_facet | Julia A. Tree Helen Flick-Smith Michael J. Elmore Caroline A. Rowland |
| author_sort | Julia A. Tree |
| collection | DOAJ |
| description | Understanding the interactions between host and pathogen is important for the development and assessment of medical countermeasures to infectious agents, including potential biodefence pathogens such as Bacillus anthracis, Ebola virus, and Francisella tularensis. This review focuses on technological advances which allow this interaction to be studied in much greater detail. Namely, the use of “omic” technologies (next generation sequencing, DNA, and protein microarrays) for dissecting the underlying host response to infection at the molecular level; optical imaging techniques (flow cytometry and fluorescence microscopy) for assessing cellular responses to infection; and biophotonic imaging for visualising the infectious disease process. All of these technologies hold great promise for important breakthroughs in the rational development of vaccines and therapeutics for biodefence agents. |
| format | Article |
| id | doaj-art-53cb70c04ed2496f832dc71e1e1fd48b |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-53cb70c04ed2496f832dc71e1e1fd48b2025-08-20T02:05:24ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/237043237043The Impact of “Omic” and Imaging Technologies on Assessing the Host Immune Response to Biodefence AgentsJulia A. Tree0Helen Flick-Smith1Michael J. Elmore2Caroline A. Rowland3Biodefence and PreClinical Evaluation Group, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP5 3NU, UKBiomedical Sciences Department, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UKBiodefence and PreClinical Evaluation Group, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, SP5 3NU, UKBiomedical Sciences Department, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UKUnderstanding the interactions between host and pathogen is important for the development and assessment of medical countermeasures to infectious agents, including potential biodefence pathogens such as Bacillus anthracis, Ebola virus, and Francisella tularensis. This review focuses on technological advances which allow this interaction to be studied in much greater detail. Namely, the use of “omic” technologies (next generation sequencing, DNA, and protein microarrays) for dissecting the underlying host response to infection at the molecular level; optical imaging techniques (flow cytometry and fluorescence microscopy) for assessing cellular responses to infection; and biophotonic imaging for visualising the infectious disease process. All of these technologies hold great promise for important breakthroughs in the rational development of vaccines and therapeutics for biodefence agents.http://dx.doi.org/10.1155/2014/237043 |
| spellingShingle | Julia A. Tree Helen Flick-Smith Michael J. Elmore Caroline A. Rowland The Impact of “Omic” and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents Journal of Immunology Research |
| title | The Impact of “Omic” and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents |
| title_full | The Impact of “Omic” and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents |
| title_fullStr | The Impact of “Omic” and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents |
| title_full_unstemmed | The Impact of “Omic” and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents |
| title_short | The Impact of “Omic” and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents |
| title_sort | impact of omic and imaging technologies on assessing the host immune response to biodefence agents |
| url | http://dx.doi.org/10.1155/2014/237043 |
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