Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapporo CAT study)
Objective Few data regarding the incidence of cancer-associated thromboembolism (TE) are available for Asian populations. We investigated the incidence of TE (TEi) and its risk factors among gastric and colorectal cancer (GCC) patients received chemotherapy in a daily practice setting.Design A retro...
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BMJ Publishing Group
2019-08-01
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| Online Access: | https://bmjopen.bmj.com/content/9/8/e028563.full |
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| author | Naoya Sakamoto Ayane Oba Aonuma Michio Nakamura Kentaro Sakamaki Taichi Murai Chika Matsuda Kazufumi Itaya Takayuki Sone Masataka Yagisawa Yuta Koike Ayana Endo Yoko Tsukuda Yuji Ono Atsushi Nagasaka Shuji Nishikawa Takeharu Yamanaka |
| author_facet | Naoya Sakamoto Ayane Oba Aonuma Michio Nakamura Kentaro Sakamaki Taichi Murai Chika Matsuda Kazufumi Itaya Takayuki Sone Masataka Yagisawa Yuta Koike Ayana Endo Yoko Tsukuda Yuji Ono Atsushi Nagasaka Shuji Nishikawa Takeharu Yamanaka |
| author_sort | Naoya Sakamoto |
| collection | DOAJ |
| description | Objective Few data regarding the incidence of cancer-associated thromboembolism (TE) are available for Asian populations. We investigated the incidence of TE (TEi) and its risk factors among gastric and colorectal cancer (GCC) patients received chemotherapy in a daily practice setting.Design A retrospective cohort study.Setting A single-institutional study that used data from Sapporo City General Hospital, Japan, on patients treated between January 2008 and May 2015.Participants Five hundred Japanese GCC patients who started chemotherapy from January 2008 to May 2015.Primary and secondary outcome measures TE was diagnosed by reviewing all the reports of contrast-enhanced CT performed during the follow-up period. All types of thrombosis detected by CT or additional imaging tests, such as venous TE, arterial TE and cerebral infarction, were defined as TE. Medical records of all identified patients were reviewed and potential risk factors for TE, including clinicopathological backgrounds, were collected. We defined the following patients as ‘active cancer’; patients with unresectable advanced GCC, cancer recurrence during or after completing adjuvant chemotherapy and/or presence of other malignant tumours.Results Of the 500 patients, 70 patients (14.0%) developed TE during the follow-up period. TEi was 9.2% and 17.3% in GCC patients, 18.1% and 3.5% in active and non-active cancer patients, and 24.0% and 12.9% in multiple and single primary, respectively. Multivariate logistic regression analysis showed that colorectal cancer (CRC) (OR 2.371; 95% CI 1.328 to 4.233), active cancer (OR 7.593; 95% CI 2.950 to 19.543) and multiple primary (OR 2.527; 95% CI 1.189 to 5.370) were independently associated with TEi.Conclusion TEi was 14.0% among Japanese GCC patients received chemotherapy, and was significantly higher among patients with CRC, active cancer and multiple primary than among those with gastric cancer, non-active cancer and single primary, respectively.Trial registration number UMIN000018912. |
| format | Article |
| id | doaj-art-53c6b5c28abe444493158ca587bf22a2 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-53c6b5c28abe444493158ca587bf22a22025-08-20T01:52:48ZengBMJ Publishing GroupBMJ Open2044-60552019-08-019810.1136/bmjopen-2018-028563Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapporo CAT study)Naoya Sakamoto0Ayane Oba Aonuma1Michio Nakamura2Kentaro Sakamaki3Taichi Murai4Chika Matsuda5Kazufumi Itaya6Takayuki Sone7Masataka Yagisawa8Yuta Koike9Ayana Endo10Yoko Tsukuda11Yuji Ono12Atsushi Nagasaka13Shuji Nishikawa14Takeharu Yamanaka152 Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan2 Department of Biostatistics and Bioinformatics, University of Tokyo, Tokyo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan3 Department of Gastroenterology, National Cancer Center Hospital East, Kashiwa, JapanDepartment of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan1 Department of Gastroenterology, Sapporo City General Hospital, Sapporo, JapanDepartment of Biostatics, Yokohama City University, Yokohama, Kanagawa, JapanObjective Few data regarding the incidence of cancer-associated thromboembolism (TE) are available for Asian populations. We investigated the incidence of TE (TEi) and its risk factors among gastric and colorectal cancer (GCC) patients received chemotherapy in a daily practice setting.Design A retrospective cohort study.Setting A single-institutional study that used data from Sapporo City General Hospital, Japan, on patients treated between January 2008 and May 2015.Participants Five hundred Japanese GCC patients who started chemotherapy from January 2008 to May 2015.Primary and secondary outcome measures TE was diagnosed by reviewing all the reports of contrast-enhanced CT performed during the follow-up period. All types of thrombosis detected by CT or additional imaging tests, such as venous TE, arterial TE and cerebral infarction, were defined as TE. Medical records of all identified patients were reviewed and potential risk factors for TE, including clinicopathological backgrounds, were collected. We defined the following patients as ‘active cancer’; patients with unresectable advanced GCC, cancer recurrence during or after completing adjuvant chemotherapy and/or presence of other malignant tumours.Results Of the 500 patients, 70 patients (14.0%) developed TE during the follow-up period. TEi was 9.2% and 17.3% in GCC patients, 18.1% and 3.5% in active and non-active cancer patients, and 24.0% and 12.9% in multiple and single primary, respectively. Multivariate logistic regression analysis showed that colorectal cancer (CRC) (OR 2.371; 95% CI 1.328 to 4.233), active cancer (OR 7.593; 95% CI 2.950 to 19.543) and multiple primary (OR 2.527; 95% CI 1.189 to 5.370) were independently associated with TEi.Conclusion TEi was 14.0% among Japanese GCC patients received chemotherapy, and was significantly higher among patients with CRC, active cancer and multiple primary than among those with gastric cancer, non-active cancer and single primary, respectively.Trial registration number UMIN000018912.https://bmjopen.bmj.com/content/9/8/e028563.full |
| spellingShingle | Naoya Sakamoto Ayane Oba Aonuma Michio Nakamura Kentaro Sakamaki Taichi Murai Chika Matsuda Kazufumi Itaya Takayuki Sone Masataka Yagisawa Yuta Koike Ayana Endo Yoko Tsukuda Yuji Ono Atsushi Nagasaka Shuji Nishikawa Takeharu Yamanaka Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapporo CAT study) BMJ Open |
| title | Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapporo CAT study) |
| title_full | Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapporo CAT study) |
| title_fullStr | Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapporo CAT study) |
| title_full_unstemmed | Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapporo CAT study) |
| title_short | Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapporo CAT study) |
| title_sort | incidence of cancer associated thromboembolism in japanese gastric and colorectal cancer patients receiving chemotherapy a single institutional retrospective cohort analysis sapporo cat study |
| url | https://bmjopen.bmj.com/content/9/8/e028563.full |
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