Controlled release study for captopril by using polymer carboxymethyl cellulose
The present study was done to prepare tablet for captopril (CAP) which used in the treatment of hypertension and heart failure. CAP is mainly absorbed from the proximal intestine and to a lesser extent from the stomach. The tablets of CAP were prepared by using the polymer carboxymethyl cellulose (...
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| Format: | Article |
| Language: | English |
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Tikrit University
2023-01-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/738 |
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| author | Reem Ibrahim Mahdi R.R. AL-Samarrai Ahmed A.Ahmed |
| author_facet | Reem Ibrahim Mahdi R.R. AL-Samarrai Ahmed A.Ahmed |
| author_sort | Reem Ibrahim Mahdi |
| collection | DOAJ |
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The present study was done to prepare tablet for captopril (CAP) which used in the treatment of hypertension and heart failure. CAP is mainly absorbed from the proximal intestine and to a lesser extent from the stomach. The tablets of CAP were prepared by using the polymer carboxymethyl cellulose (CMC) a captopril drug release system. The buffer solutions were use at (pH=12,7.4,8.5) as a media to release the drug similitude of the acidity index in stomach, in testiness, and blood plasma respective. It was accounted the concentrations of the drug that release in the above–mentioned solutions at the different temperature (25,30,37,40,45,) C°. The study was extended to the effect of the temperature and the acidity function on releasing the drug. The drug release from the polymers increased with the temperature and the degree of the solution acidity. It was also studied the value of stability constant that increased with the temperature.
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| format | Article |
| id | doaj-art-53c5af75b0e4467c996370d71ebafd3f |
| institution | Kabale University |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-53c5af75b0e4467c996370d71ebafd3f2025-08-20T03:29:09ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-01-0122410.25130/tjps.v22i4.738Controlled release study for captopril by using polymer carboxymethyl celluloseReem Ibrahim MahdiR.R. AL-SamarraiAhmed A.Ahmed The present study was done to prepare tablet for captopril (CAP) which used in the treatment of hypertension and heart failure. CAP is mainly absorbed from the proximal intestine and to a lesser extent from the stomach. The tablets of CAP were prepared by using the polymer carboxymethyl cellulose (CMC) a captopril drug release system. The buffer solutions were use at (pH=12,7.4,8.5) as a media to release the drug similitude of the acidity index in stomach, in testiness, and blood plasma respective. It was accounted the concentrations of the drug that release in the above–mentioned solutions at the different temperature (25,30,37,40,45,) C°. The study was extended to the effect of the temperature and the acidity function on releasing the drug. The drug release from the polymers increased with the temperature and the degree of the solution acidity. It was also studied the value of stability constant that increased with the temperature. https://tjpsj.org/index.php/tjps/article/view/738Controlled releasecaptoprilpolymer carboxymethyl cellulose |
| spellingShingle | Reem Ibrahim Mahdi R.R. AL-Samarrai Ahmed A.Ahmed Controlled release study for captopril by using polymer carboxymethyl cellulose Tikrit Journal of Pure Science Controlled release captopril polymer carboxymethyl cellulose |
| title | Controlled release study for captopril by using polymer carboxymethyl cellulose |
| title_full | Controlled release study for captopril by using polymer carboxymethyl cellulose |
| title_fullStr | Controlled release study for captopril by using polymer carboxymethyl cellulose |
| title_full_unstemmed | Controlled release study for captopril by using polymer carboxymethyl cellulose |
| title_short | Controlled release study for captopril by using polymer carboxymethyl cellulose |
| title_sort | controlled release study for captopril by using polymer carboxymethyl cellulose |
| topic | Controlled release captopril polymer carboxymethyl cellulose |
| url | https://tjpsj.org/index.php/tjps/article/view/738 |
| work_keys_str_mv | AT reemibrahimmahdi controlledreleasestudyforcaptoprilbyusingpolymercarboxymethylcellulose AT rralsamarrai controlledreleasestudyforcaptoprilbyusingpolymercarboxymethylcellulose AT ahmedaahmed controlledreleasestudyforcaptoprilbyusingpolymercarboxymethylcellulose |