Magnetoencephalographic brain activity evoked by the optic-flow task is correlated with β-amyloid burden and parahippocampal atrophy
Visuospatial perception is often impaired in people with Alzheimer’s disease (AD). Because visuospatial information is thought to be processed in the visual dorsal stream, it is believed that brain activities in the dorsal stream will be altered in AD patients. In this study, we investigated whether...
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Elsevier
2024-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158224001414 |
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| author | Shoko Tsuchimine Kiwamu Kudo Junji Komatsu Shutaro Shibata Sachiko Kitagawa Yoshihiro Misaka Moeko Noguchi-Shinohara Kenjiro Ono Hirofumi Morise Takashi Asakawa |
| author_facet | Shoko Tsuchimine Kiwamu Kudo Junji Komatsu Shutaro Shibata Sachiko Kitagawa Yoshihiro Misaka Moeko Noguchi-Shinohara Kenjiro Ono Hirofumi Morise Takashi Asakawa |
| author_sort | Shoko Tsuchimine |
| collection | DOAJ |
| description | Visuospatial perception is often impaired in people with Alzheimer’s disease (AD). Because visuospatial information is thought to be processed in the visual dorsal stream, it is believed that brain activities in the dorsal stream will be altered in AD patients. In this study, we investigated whether regional brain activity related to visuospatial perception were associated with AD progression markers. An optic-flow task, which activates the dorsal stream associated with visuospatial perception, was performed, and the brain activities evoked by the task were evaluated using magnetoencephalography (MEG). First, we evaluated the responses to optic-flow stimuli in 21 cognitively unimpaired participants and determined the regions of interest (ROIs) where optic-flow activities were activated. Task-related activations were observed in 14 cortical regions including the dorsal stream: the right and left medial ventral occipital cortex (MVOcC), lateral occipital cortex (LOcC), precuneus (Pcun), inferior parietal lobule (IPL), superior parietal lobule (SPL), posterior superior temporal sulcus (pSTS), and fusiform gyri (FuG). Next, we performed correlation analyses between task-related activity in each ROI and two AD progression markers, global amyloid burden and parahippocampal gyrus (PHG) volume, for 25 participants who underwent amyloid positron emission tomography (PET) scans. We found that the global amyloid burden was negatively correlated with task-related activity in the left MVOcC and right SPL [r = -0.488 (p = 0.013) and r = -0.421 (p = 0.038), respectively]. Furthermore, significant positive correlations were observed between PHG volume and task-related activity in both the left and right SPL [r = 0.500 (p = 0.011) and r = 0.549 (p = 0.005), respectively]. Since the SPL is known to be responsible for visuospatial perception, these results suggest that MEG neuronal activity of patients performing the optic-flow activity can detect changes in brain activity associated with visuospatial impairment related to AD. |
| format | Article |
| id | doaj-art-53c2ce6a52134f7a9d444fd747718e2b |
| institution | DOAJ |
| issn | 2213-1582 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
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| series | NeuroImage: Clinical |
| spelling | doaj-art-53c2ce6a52134f7a9d444fd747718e2b2025-08-20T02:49:00ZengElsevierNeuroImage: Clinical2213-15822024-01-014410370010.1016/j.nicl.2024.103700Magnetoencephalographic brain activity evoked by the optic-flow task is correlated with β-amyloid burden and parahippocampal atrophyShoko Tsuchimine0Kiwamu Kudo1Junji Komatsu2Shutaro Shibata3Sachiko Kitagawa4Yoshihiro Misaka5Moeko Noguchi-Shinohara6Kenjiro Ono7Hirofumi Morise8Takashi Asakawa9Medical Imaging Business Center, Ricoh Company, Ltd., Kanazawa, Japan; Corresponding author.Medical Imaging Business Center, Ricoh Company, Ltd., Kanazawa, JapanDepartment of Neurology and Neurobiology of Aging, Kanazawa University, Kanazawa, JapanDepartment of Neurology and Neurobiology of Aging, Kanazawa University, Kanazawa, JapanDepartment of Neurology and Neurobiology of Aging, Kanazawa University, Kanazawa, JapanMedical Imaging Business Center, Ricoh Company, Ltd., Kanazawa, JapanDepartment of Preemptive Medicine of Dementia, Kanazawa University, Kanazawa, JapanDepartment of Preemptive Medicine of Dementia, Kanazawa University, Kanazawa, JapanMedical Imaging Business Center, Ricoh Company, Ltd., Kanazawa, JapanMedical Imaging Business Center, Ricoh Company, Ltd., Kanazawa, JapanVisuospatial perception is often impaired in people with Alzheimer’s disease (AD). Because visuospatial information is thought to be processed in the visual dorsal stream, it is believed that brain activities in the dorsal stream will be altered in AD patients. In this study, we investigated whether regional brain activity related to visuospatial perception were associated with AD progression markers. An optic-flow task, which activates the dorsal stream associated with visuospatial perception, was performed, and the brain activities evoked by the task were evaluated using magnetoencephalography (MEG). First, we evaluated the responses to optic-flow stimuli in 21 cognitively unimpaired participants and determined the regions of interest (ROIs) where optic-flow activities were activated. Task-related activations were observed in 14 cortical regions including the dorsal stream: the right and left medial ventral occipital cortex (MVOcC), lateral occipital cortex (LOcC), precuneus (Pcun), inferior parietal lobule (IPL), superior parietal lobule (SPL), posterior superior temporal sulcus (pSTS), and fusiform gyri (FuG). Next, we performed correlation analyses between task-related activity in each ROI and two AD progression markers, global amyloid burden and parahippocampal gyrus (PHG) volume, for 25 participants who underwent amyloid positron emission tomography (PET) scans. We found that the global amyloid burden was negatively correlated with task-related activity in the left MVOcC and right SPL [r = -0.488 (p = 0.013) and r = -0.421 (p = 0.038), respectively]. Furthermore, significant positive correlations were observed between PHG volume and task-related activity in both the left and right SPL [r = 0.500 (p = 0.011) and r = 0.549 (p = 0.005), respectively]. Since the SPL is known to be responsible for visuospatial perception, these results suggest that MEG neuronal activity of patients performing the optic-flow activity can detect changes in brain activity associated with visuospatial impairment related to AD.http://www.sciencedirect.com/science/article/pii/S2213158224001414Alzheimer’s diseaseMagnetoencephalographyOptic-flow taskVisuospatial impairmentSuperior parietal lobuleParahippocampal gyrus volume |
| spellingShingle | Shoko Tsuchimine Kiwamu Kudo Junji Komatsu Shutaro Shibata Sachiko Kitagawa Yoshihiro Misaka Moeko Noguchi-Shinohara Kenjiro Ono Hirofumi Morise Takashi Asakawa Magnetoencephalographic brain activity evoked by the optic-flow task is correlated with β-amyloid burden and parahippocampal atrophy NeuroImage: Clinical Alzheimer’s disease Magnetoencephalography Optic-flow task Visuospatial impairment Superior parietal lobule Parahippocampal gyrus volume |
| title | Magnetoencephalographic brain activity evoked by the optic-flow task is correlated with β-amyloid burden and parahippocampal atrophy |
| title_full | Magnetoencephalographic brain activity evoked by the optic-flow task is correlated with β-amyloid burden and parahippocampal atrophy |
| title_fullStr | Magnetoencephalographic brain activity evoked by the optic-flow task is correlated with β-amyloid burden and parahippocampal atrophy |
| title_full_unstemmed | Magnetoencephalographic brain activity evoked by the optic-flow task is correlated with β-amyloid burden and parahippocampal atrophy |
| title_short | Magnetoencephalographic brain activity evoked by the optic-flow task is correlated with β-amyloid burden and parahippocampal atrophy |
| title_sort | magnetoencephalographic brain activity evoked by the optic flow task is correlated with β amyloid burden and parahippocampal atrophy |
| topic | Alzheimer’s disease Magnetoencephalography Optic-flow task Visuospatial impairment Superior parietal lobule Parahippocampal gyrus volume |
| url | http://www.sciencedirect.com/science/article/pii/S2213158224001414 |
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