The association of metabolic positron emission tomography/computed tomography parameters with survival in small cell lung cancer
BACKGROUND: Small cell lung cancer (SCLC) is a lung malignancy with a poor prognosis and metastases at the time of diagnosis. There is limited experience using positron emission tomography/computed tomography (PET/CT) for SCLC diagnosis, staging, and follow-up. OBJECTIVE: Investigate the survival ef...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
King Faisal Specialist Hospital and Research Centre
2025-01-01
|
| Series: | Annals of Saudi Medicine |
| Online Access: | http://www.annsaudimed.net/doi/10.5144/0256-4947.2025.25 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850039077379768320 |
|---|---|
| author | Merve Ayık Türk Berna Kömürcüoğlu Nurşin Agüloğlu Tuğçe Doksöz Çiftçi Mücahit Fidan Sinan Çolak Özgür Batum |
| author_facet | Merve Ayık Türk Berna Kömürcüoğlu Nurşin Agüloğlu Tuğçe Doksöz Çiftçi Mücahit Fidan Sinan Çolak Özgür Batum |
| author_sort | Merve Ayık Türk |
| collection | DOAJ |
| description | BACKGROUND: Small cell lung cancer (SCLC) is a lung malignancy with a poor prognosis and metastases at the time of diagnosis. There is limited experience using positron emission tomography/computed tomography (PET/CT) for SCLC diagnosis, staging, and follow-up. OBJECTIVE: Investigate the survival effect of primary tumor standardized uptake value max (SUVmax), SUV mean, metabolic tumor volume (MTV), total lesion glucose (TLG), bone marrow SUV (BM), and bone marrow to liver ratio (BLR) in SCLC. DESIGN: Retrospective SETTING: Single center in Turkey PATIENTS AND METHODS: Patients who were cyto/histologically diagnosed with SCLC and had PET/CT simultaneous with the diagnosis were included in the study. MAIN OUTCOME MEASURES: The effect of PET/CT parameters on overall survival (OS) and progression-free survival (PFS). SAMPLE SIZE: 304 RESULTS: The 5-year OS median value was 14.62 months, and the 5-year PFS was 13.01 months. In Kaplan-Meier analysis, SUVmax, MTV, and TLG were statistically significant variables in OS (P=.03; P<.001; P<.001, respectively). MTV and TLG were significant in PFS (P<.001; P=.0003, respectively). In the multivariate analysis, MTV was an independent PET/CT parameter associated with OS (P=.003), stage of disease (P=.012), SUVmax (P=.003), MTV (P=.016), and TLG (P=.005) were significant variables in PFS. CONCLUSION: In our study, MTV was an independent parameter that can be used to predict survival in SCLC. Considering the effect of MTV, a metabolic PET/CT parameter on survival, it can be recommended for clinical use as a standard measure of evaluation in PET/CT reports, just like SUVmax. LIMITATIONS: The first limitation was the single-center and retrospective design of the study. Due to the retrospective design of the study, weight loss, performance status, and smoking history could not be obtained from every patient. Second, inaccurate registration of PET and CT images due to patient respiratory movements may affect measurements. |
| format | Article |
| id | doaj-art-53bfa32d61074162a4bf7c43bd53ded8 |
| institution | DOAJ |
| issn | 0256-4947 0975-4466 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj-art-53bfa32d61074162a4bf7c43bd53ded82025-08-20T02:56:27ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662025-01-01451253210.5144/0256-4947.2025.25The association of metabolic positron emission tomography/computed tomography parameters with survival in small cell lung cancerMerve Ayık Türk0Berna Kömürcüoğlu1Nurşin Agüloğlu2Tuğçe Doksöz Çiftçi3Mücahit Fidan4Sinan Çolak5Özgür Batum6From the Department of Pulmonology, University of Health Sciences Izmir Bozyaka Training and Research Hospital, Izmir, TurkeyFrom the Department of Chest Diseases, University of Health Sciences Dr. Suat Seren Chest Diseases Hospital, Izmir, TurkeyFrom the Department of Nuclear Medicine, University of Health Sciences Dr. Suat Seren Chest Diseases Hospitall, Izmir, TurkeyFrom the Department of Nuclear Medicine, University of Health Sciences Dr. Suat Seren Chest Diseases Hospitall, Izmir, TurkeyFrom the Department of Pulmonology, Ministry of Health Buca Seyfi Demirsoy Training and Research Hospital, Izmir, TurkeyFrom the Department of Pulmonology, University of Health Sciences Izmir Bozyaka Training and Research Hospital, Izmir, TurkeyFrom the Department of Chest Diseases, University of Health Sciences Dr. Suat Seren Chest Diseases Hospital, Izmir, TurkeyBACKGROUND: Small cell lung cancer (SCLC) is a lung malignancy with a poor prognosis and metastases at the time of diagnosis. There is limited experience using positron emission tomography/computed tomography (PET/CT) for SCLC diagnosis, staging, and follow-up. OBJECTIVE: Investigate the survival effect of primary tumor standardized uptake value max (SUVmax), SUV mean, metabolic tumor volume (MTV), total lesion glucose (TLG), bone marrow SUV (BM), and bone marrow to liver ratio (BLR) in SCLC. DESIGN: Retrospective SETTING: Single center in Turkey PATIENTS AND METHODS: Patients who were cyto/histologically diagnosed with SCLC and had PET/CT simultaneous with the diagnosis were included in the study. MAIN OUTCOME MEASURES: The effect of PET/CT parameters on overall survival (OS) and progression-free survival (PFS). SAMPLE SIZE: 304 RESULTS: The 5-year OS median value was 14.62 months, and the 5-year PFS was 13.01 months. In Kaplan-Meier analysis, SUVmax, MTV, and TLG were statistically significant variables in OS (P=.03; P<.001; P<.001, respectively). MTV and TLG were significant in PFS (P<.001; P=.0003, respectively). In the multivariate analysis, MTV was an independent PET/CT parameter associated with OS (P=.003), stage of disease (P=.012), SUVmax (P=.003), MTV (P=.016), and TLG (P=.005) were significant variables in PFS. CONCLUSION: In our study, MTV was an independent parameter that can be used to predict survival in SCLC. Considering the effect of MTV, a metabolic PET/CT parameter on survival, it can be recommended for clinical use as a standard measure of evaluation in PET/CT reports, just like SUVmax. LIMITATIONS: The first limitation was the single-center and retrospective design of the study. Due to the retrospective design of the study, weight loss, performance status, and smoking history could not be obtained from every patient. Second, inaccurate registration of PET and CT images due to patient respiratory movements may affect measurements.http://www.annsaudimed.net/doi/10.5144/0256-4947.2025.25 |
| spellingShingle | Merve Ayık Türk Berna Kömürcüoğlu Nurşin Agüloğlu Tuğçe Doksöz Çiftçi Mücahit Fidan Sinan Çolak Özgür Batum The association of metabolic positron emission tomography/computed tomography parameters with survival in small cell lung cancer Annals of Saudi Medicine |
| title | The association of metabolic positron emission tomography/computed tomography parameters with survival in small cell lung cancer |
| title_full | The association of metabolic positron emission tomography/computed tomography parameters with survival in small cell lung cancer |
| title_fullStr | The association of metabolic positron emission tomography/computed tomography parameters with survival in small cell lung cancer |
| title_full_unstemmed | The association of metabolic positron emission tomography/computed tomography parameters with survival in small cell lung cancer |
| title_short | The association of metabolic positron emission tomography/computed tomography parameters with survival in small cell lung cancer |
| title_sort | association of metabolic positron emission tomography computed tomography parameters with survival in small cell lung cancer |
| url | http://www.annsaudimed.net/doi/10.5144/0256-4947.2025.25 |
| work_keys_str_mv | AT merveayıkturk theassociationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT bernakomurcuoglu theassociationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT nursinaguloglu theassociationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT tugcedoksozciftci theassociationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT mucahitfidan theassociationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT sinancolak theassociationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT ozgurbatum theassociationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT merveayıkturk associationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT bernakomurcuoglu associationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT nursinaguloglu associationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT tugcedoksozciftci associationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT mucahitfidan associationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT sinancolak associationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer AT ozgurbatum associationofmetabolicpositronemissiontomographycomputedtomographyparameterswithsurvivalinsmallcelllungcancer |