Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis
Hydrogen-rich water (HRW) shows excellent antibacterial, anti-inflammatory, antioxidant, and wound-healing properties and plays a positive role in the treatment of various diseases, such as brain injury, kidney injury, and periodontitis. Current studies found that HRW can inhibit periodontopathogeni...
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2025-01-01
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| Series: | 口腔疾病防治 |
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| Online Access: | https://www.kqjbfz.com/fileup/2096-1456/PDF/2096-1456（2025）01--07.pdf |
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| author | LIU Fushuang, WEI Xiaoxuan, ZHOU Jianpeng, WANG Jun |
| author_facet | LIU Fushuang, WEI Xiaoxuan, ZHOU Jianpeng, WANG Jun |
| author_sort | LIU Fushuang, WEI Xiaoxuan, ZHOU Jianpeng, WANG Jun |
| collection | DOAJ |
| description | Hydrogen-rich water (HRW) shows excellent antibacterial, anti-inflammatory, antioxidant, and wound-healing properties and plays a positive role in the treatment of various diseases, such as brain injury, kidney injury, and periodontitis. Current studies found that HRW can inhibit periodontopathogenic biofilm formation, inhibit oral connective tissue and bone tissue destruction, and show anti-inflammatory and antioxidant properties in periodontitis. Additionally, HRW can alleviate periodontal tissue damage by inhibiting oxidative stress and up-regulating the expression of antioxidant enzymes, such as glutathione peroxidase and superoxide dismutase. HRW exerts anti-inflammatory effects by regulating the nuclear factor erythroid 2-related factor 2 and mitogen-activated protein kinase pathways, which are closely associated with inflammation. Additionally, HRW inhibits the expression of inflammatory cytokines, such as interleukins, inhibits the growth and proliferation of bacterial plaque biofilms, and down-regulates glycosyltransferases and glucan-binding proteins to prevent bacterial adhesion and subsequent development of periodontitis. Furthermore, HRW has a positive effect on the expression of various cell growth factors, α-smooth muscle actin, and type I collagen, which promotes wound healing. Current clinical studies have demonstrated the biological safety of HRW (to a certain extent) and reported no adverse reactions. However, most studies on HRW in oral diseases are preclinical <i>in vivo</i> and <i>in vitro</i> studies. Therefore, further clinical studies are required to validate the therapeutic significance and optimal therapeutic regimen of HRW in human periodontitis. This article aims to review the therapeutic role and the underlying mechanisms of HRW in periodontitis. |
| format | Article |
| id | doaj-art-53bee16eb0a94dafba4e8713a087ab07 |
| institution | Kabale University |
| issn | 2096-1456 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj-art-53bee16eb0a94dafba4e8713a087ab072025-01-22T03:36:02ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562025-01-01331687410.12016/j.issn.2096-1456.202440004Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitisLIU Fushuang, WEI Xiaoxuan, ZHOU Jianpeng, WANG Jun0State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaHydrogen-rich water (HRW) shows excellent antibacterial, anti-inflammatory, antioxidant, and wound-healing properties and plays a positive role in the treatment of various diseases, such as brain injury, kidney injury, and periodontitis. Current studies found that HRW can inhibit periodontopathogenic biofilm formation, inhibit oral connective tissue and bone tissue destruction, and show anti-inflammatory and antioxidant properties in periodontitis. Additionally, HRW can alleviate periodontal tissue damage by inhibiting oxidative stress and up-regulating the expression of antioxidant enzymes, such as glutathione peroxidase and superoxide dismutase. HRW exerts anti-inflammatory effects by regulating the nuclear factor erythroid 2-related factor 2 and mitogen-activated protein kinase pathways, which are closely associated with inflammation. Additionally, HRW inhibits the expression of inflammatory cytokines, such as interleukins, inhibits the growth and proliferation of bacterial plaque biofilms, and down-regulates glycosyltransferases and glucan-binding proteins to prevent bacterial adhesion and subsequent development of periodontitis. Furthermore, HRW has a positive effect on the expression of various cell growth factors, α-smooth muscle actin, and type I collagen, which promotes wound healing. Current clinical studies have demonstrated the biological safety of HRW (to a certain extent) and reported no adverse reactions. However, most studies on HRW in oral diseases are preclinical <i>in vivo</i> and <i>in vitro</i> studies. Therefore, further clinical studies are required to validate the therapeutic significance and optimal therapeutic regimen of HRW in human periodontitis. This article aims to review the therapeutic role and the underlying mechanisms of HRW in periodontitis.https://www.kqjbfz.com/fileup/2096-1456/PDF/2096-1456（2025）01--07.pdfmolecular hydrogen|hydrogen-rich water|periodontitis|dental plaque biofilm|wound healing|oxidative stress|inflammation|cell growth factors|anti-bacteria |
| spellingShingle | LIU Fushuang, WEI Xiaoxuan, ZHOU Jianpeng, WANG Jun Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis 口腔疾病防治 molecular hydrogen|hydrogen-rich water|periodontitis|dental plaque biofilm|wound healing|oxidative stress|inflammation|cell growth factors|anti-bacteria |
| title | Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis |
| title_full | Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis |
| title_fullStr | Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis |
| title_full_unstemmed | Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis |
| title_short | Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis |
| title_sort | research progress on the therapeutic roles and mechanisms of hydrogen rich water in periodontitis |
| topic | molecular hydrogen|hydrogen-rich water|periodontitis|dental plaque biofilm|wound healing|oxidative stress|inflammation|cell growth factors|anti-bacteria |
| url | https://www.kqjbfz.com/fileup/2096-1456/PDF/2096-1456（2025）01--07.pdf |
| work_keys_str_mv | AT liufushuangweixiaoxuanzhoujianpengwangjun researchprogressonthetherapeuticrolesandmechanismsofhydrogenrichwaterinperiodontitis |