Research advances in probiotic fermentation of Chinese herbal medicines
Abstract Chinese herbal medicines (CHM) have been used to cure diseases for thousands of years. However, the bioactive ingredients of CHM are complex, and some CHM natural products cannot be directly absorbed by humans and animals. Moreover, the contents of most bioactive ingredients in CHM are low,...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | iMeta |
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| Online Access: | https://doi.org/10.1002/imt2.93 |
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| author | Xiaoling Zhang Qin Miao Chengxue Pan Jia Yin Leli Wang Lingbo Qu Yulong Yin Yongjun Wei |
| author_facet | Xiaoling Zhang Qin Miao Chengxue Pan Jia Yin Leli Wang Lingbo Qu Yulong Yin Yongjun Wei |
| author_sort | Xiaoling Zhang |
| collection | DOAJ |
| description | Abstract Chinese herbal medicines (CHM) have been used to cure diseases for thousands of years. However, the bioactive ingredients of CHM are complex, and some CHM natural products cannot be directly absorbed by humans and animals. Moreover, the contents of most bioactive ingredients in CHM are low, and some natural products are toxic to humans and animals. Fermentation of CHM could enhance CHM bioactivities and decrease the potential toxicities. The compositions and functions of the microorganisms play essential roles in CHM fermentation, which can affect the fermentation metabolites and pharmaceutical activities of the final fermentation products. During CHM fermentation, probiotics not only increase the contents of bioactive natural products, but also are beneficial for the host gut microbiota and immune system. This review summarizes the advantages of fermentation of CHM using probiotics, fermentation techniques, probiotic strains, and future development for CHM fermentation. Cutting‐edge microbiome and synthetic biology tools would harness microbial cell factories to produce large amounts of bioactive natural products derived from CHM with low‐cost, which would help speed up modern CHM biomanufacturing. |
| format | Article |
| id | doaj-art-53bd945906c64239a6fd95dafb99b999 |
| institution | OA Journals |
| issn | 2770-596X |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMeta |
| spelling | doaj-art-53bd945906c64239a6fd95dafb99b9992025-08-20T02:20:55ZengWileyiMeta2770-596X2023-05-0122n/an/a10.1002/imt2.93Research advances in probiotic fermentation of Chinese herbal medicinesXiaoling Zhang0Qin Miao1Chengxue Pan2Jia Yin3Leli Wang4Lingbo Qu5Yulong Yin6Yongjun Wei7School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education Zhengzhou University Zhengzhou ChinaSchool of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education Zhengzhou University Zhengzhou ChinaSchool of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education Zhengzhou University Zhengzhou ChinaHunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Science Hunan Normal University Changsha ChinaHunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Science Hunan Normal University Changsha ChinaLaboratory of Synthetic Biology, Food Laboratory of Zhongyuan Zhengzhou University Zhengzhou ChinaInstitute of Subtropical Agriculture Chinese Academy of Sciences Changsha ChinaSchool of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education Zhengzhou University Zhengzhou ChinaAbstract Chinese herbal medicines (CHM) have been used to cure diseases for thousands of years. However, the bioactive ingredients of CHM are complex, and some CHM natural products cannot be directly absorbed by humans and animals. Moreover, the contents of most bioactive ingredients in CHM are low, and some natural products are toxic to humans and animals. Fermentation of CHM could enhance CHM bioactivities and decrease the potential toxicities. The compositions and functions of the microorganisms play essential roles in CHM fermentation, which can affect the fermentation metabolites and pharmaceutical activities of the final fermentation products. During CHM fermentation, probiotics not only increase the contents of bioactive natural products, but also are beneficial for the host gut microbiota and immune system. This review summarizes the advantages of fermentation of CHM using probiotics, fermentation techniques, probiotic strains, and future development for CHM fermentation. Cutting‐edge microbiome and synthetic biology tools would harness microbial cell factories to produce large amounts of bioactive natural products derived from CHM with low‐cost, which would help speed up modern CHM biomanufacturing.https://doi.org/10.1002/imt2.93Chinese herbal medicineprobioticsfermentationmicrobiomesynthetic biology |
| spellingShingle | Xiaoling Zhang Qin Miao Chengxue Pan Jia Yin Leli Wang Lingbo Qu Yulong Yin Yongjun Wei Research advances in probiotic fermentation of Chinese herbal medicines iMeta Chinese herbal medicine probiotics fermentation microbiome synthetic biology |
| title | Research advances in probiotic fermentation of Chinese herbal medicines |
| title_full | Research advances in probiotic fermentation of Chinese herbal medicines |
| title_fullStr | Research advances in probiotic fermentation of Chinese herbal medicines |
| title_full_unstemmed | Research advances in probiotic fermentation of Chinese herbal medicines |
| title_short | Research advances in probiotic fermentation of Chinese herbal medicines |
| title_sort | research advances in probiotic fermentation of chinese herbal medicines |
| topic | Chinese herbal medicine probiotics fermentation microbiome synthetic biology |
| url | https://doi.org/10.1002/imt2.93 |
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