Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models

Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models

Abstract Background Cognitive reserve allows for resilience to neuropathology, potentially through active compensation. Here, we examine ex vivo electrophysiological evidence for active compensation in Alzheimer’s disease (AD) focusing on the cholinergic innervation of layer 6 in prefrontal cortex....

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Bibliographic Details
Main Authors: Saige K. Power, Sridevi Venkatesan, Sarah Qu, JoAnne McLaurin, Evelyn K. Lambe
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Cognitive reserve
Prefrontal cortex
Acetylcholine
Nicotinic receptors
Optogenetics
Online Access:https://doi.org/10.1186/s40035-024-00452-7
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