Overexpression of Cx43: Is It an Effective Approach for the Treatment of Cardiovascular Diseases?

Overexpression of Cx43: Is It an Effective Approach for the Treatment of Cardiovascular Diseases?

In the heart, Connexin 43 (Cx43) is involved in intercellular communication through gap junctions and exosomes. In addition, Cx43-formed hemichannels at the plasma membrane are important for ion homeostasis and cellular volume regulation. Through its localization within nuclei and mitochondria, Cx43...

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Bibliographic Details
Main Authors: Kerstin Boengler, Beatrice Mantuano, Shira Toledano, Ofer Binah, Rainer Schulz
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomolecules
Subjects:
connexin
gap junction
mitochondria
hemichannel
cardiac disease
Online Access:https://www.mdpi.com/2218-273X/15/3/370
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