The Wnt pathway induces a naïve-like subpopulation in primed stem cells, while NME7AB leads to a homogeneous naïve-like population.

The Wnt pathway induces a naïve-like subpopulation in primed stem cells, while NME7AB leads to a homogeneous naïve-like population.

The literature is replete with conflicting reports as to whether the Wnt/β-catenin pathway induces human stem cell differentiation or pluripotency. Recently, scientists showed that human stem cells expressing low levels of active β-catenin preferentially differentiate down a neuroectoderm lineage, w...

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Bibliographic Details
Main Authors: Kevin R Yi, Jac-Leen S S Nash, Mark G Carter, Danica M Walkley, Jiwon Jang, Benoit J Smagghe, Andrew K Stewart, Cynthia C Bamdad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0325997
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