Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission
Chronic stress results in neurochemical, physiological, immune, molecular, cellular, and structural changes in the brain and often dampens the cognition. The hippocampus has been one major focus in studying the stress responsivity and neural mechanisms underlying depression. Both acute and chronic s...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/9360203 |
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| _version_ | 1832564193028472832 |
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| author | Min Lin Gonglin Hou Ying Zhao Ti-Fei Yuan |
| author_facet | Min Lin Gonglin Hou Ying Zhao Ti-Fei Yuan |
| author_sort | Min Lin |
| collection | DOAJ |
| description | Chronic stress results in neurochemical, physiological, immune, molecular, cellular, and structural changes in the brain and often dampens the cognition. The hippocampus has been one major focus in studying the stress responsivity and neural mechanisms underlying depression. Both acute and chronic stress stimuli lead to dynamic changes in excitatory transmission in the hippocampus. The present study examined the potential effects of spontaneous recovery after chronic stress on spatial memory function and glutamatergic transmission in the hippocampus. The results showed that chronic unpredicted mild stress transiently increased AMPA receptor GluA2/3 subunit expression, together with elevated PICK-1 protein expression. Spontaneous recovery restored the behavioral deficits in Barnes maze test, as well as the glutamate receptor expression changes. In conclusion, spontaneous recovery acts as an important mechanism in system homeostasis. |
| format | Article |
| id | doaj-art-53adc32466b14dddbefa348b02488eb8 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-53adc32466b14dddbefa348b02488eb82025-02-03T01:11:37ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/93602039360203Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic TransmissionMin Lin0Gonglin Hou1Ying Zhao2Ti-Fei Yuan3Department of Psychology, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, ChinaDepartment of Psychology, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, ChinaDepartment of Psychology, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, ChinaShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaChronic stress results in neurochemical, physiological, immune, molecular, cellular, and structural changes in the brain and often dampens the cognition. The hippocampus has been one major focus in studying the stress responsivity and neural mechanisms underlying depression. Both acute and chronic stress stimuli lead to dynamic changes in excitatory transmission in the hippocampus. The present study examined the potential effects of spontaneous recovery after chronic stress on spatial memory function and glutamatergic transmission in the hippocampus. The results showed that chronic unpredicted mild stress transiently increased AMPA receptor GluA2/3 subunit expression, together with elevated PICK-1 protein expression. Spontaneous recovery restored the behavioral deficits in Barnes maze test, as well as the glutamate receptor expression changes. In conclusion, spontaneous recovery acts as an important mechanism in system homeostasis.http://dx.doi.org/10.1155/2018/9360203 |
| spellingShingle | Min Lin Gonglin Hou Ying Zhao Ti-Fei Yuan Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission Neural Plasticity |
| title | Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission |
| title_full | Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission |
| title_fullStr | Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission |
| title_full_unstemmed | Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission |
| title_short | Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission |
| title_sort | recovery of chronic stress triggered changes of hippocampal glutamatergic transmission |
| url | http://dx.doi.org/10.1155/2018/9360203 |
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