Proanthocyanidins protects 3-NPA-induced ovarian function decline by activating SESTRIN2-NRF2-mediated oxidative stress in mice

Proanthocyanidins protects 3-NPA-induced ovarian function decline by activating SESTRIN2-NRF2-mediated oxidative stress in mice

Abstract Abnormal apoptosis of ovarian cells caused by oxidative stress is an important cause of premature ovarian failure (POF). Previous studies revealed that proanthocyanidins (PCs) are powerful natural antioxidants that can safely prevent oxidative damage in humans. However, the protective effec...

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Bibliographic Details
Main Authors: Yupei Huang, Yanfan Cui, Jian Huang, Huang Xinyuan, Wang Zihang, Tao Luo, Jia Li
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Follicle atresia
SESTRIN2-NRF2 pathway
Oxidative stress
Ovarian function
Premature ovarian failure
Online Access:https://doi.org/10.1038/s41598-024-76743-w
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