Prediction of inflammation cytokines for acute kidney injury after congenital heart disease surgery in children
ObjectiveTo explore the value of inflammation cytokines for predicting the postoperative occurrence of acute kidney injury （AKI） after surgery for congenital heart disease in children.MethodsFrom February 2018 to November 2020， 139 cases of congenital heart disease undergoing cardiopulmonary bypass...
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Editorial Department of Journal of Clinical Nephrology
2022-07-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.07.007 |
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| author | Sun Ling Xie Xing-yuan Qu Qiang Liu Jing Xiao Fei |
| author_facet | Sun Ling Xie Xing-yuan Qu Qiang Liu Jing Xiao Fei |
| author_sort | Sun Ling |
| collection | DOAJ |
| description | ObjectiveTo explore the value of inflammation cytokines for predicting the postoperative occurrence of acute kidney injury （AKI） after surgery for congenital heart disease in children.MethodsFrom February 2018 to November 2020， 139 cases of congenital heart disease undergoing cardiopulmonary bypass surgery were recruited and divided into two groups of AKI and non-AKI. Children in AKI group were further divided into AKI with progression and AKI without progression according to whether or not renal function worsened persistently. The groups were compared with regards to the levels of interleukin （IL）-2， IL-4， IL-6， IL-8， IL-10， tumor necrosis factor-α （TNF-α）， interferon-γ （IFN-γ） in sera and liver fatty acid binding protein （L-FABP）， neutrophil gelatinase-associated lipocalin （NGAL） in urine. Correlation analysis was performed between those factors and AKI and AKI occurring predicated by area under the ROC curve （AUC）.ResultsCardiopulmonary bypass （CBP） time ［（133.6±31.5） min <italic>vs</italic> （102.8±19.8） min， 142.6（52.5， 288.6） min <italic>vs</italic> 115.7（64.8， 69.4） min］， aortic cross-clamp time ［（68.5±29.7） min <italic>vs</italic> （52.0±36.5） min， 73（56.5， 93.8） min <italic>vs</italic> 56（40.5， 72.2） min］， PICU stay ［9.7（6.4， 17.2） d <italic>vs</italic> 4.2（2.2， 7.2） d， 11.5（10.6， 15.5） d <italic>vs</italic> 5.3（4.3， 9.7） d］， hospital stay ［15.7（11.3， 19.2） d <italic>vs</italic> 9.5（8.5， 13.5） d， 21.7（15.8， 32.6） d <italic>vs</italic> 10.2（9.4， 17.6） d］， mechanical ventilation time ［5.7（1.4， 12.2） d <italic>vs</italic> 2.8（2.0， 8.9） d， 7.7（5.2， 18.7） d <italic>vs</italic> 4.8（2.2， 12.2） d］ of AKI and AKI with progression groupa were longer than those of non-AKI and AKI without progression groups （<italic>P</italic><0.05）. The levels of IL-2 ［2.4（1.1， 2.7）ng/L <italic>vs</italic> 0.9（0.5， 2.3） ng/L， 2.9（1.1， 3.6）ng/L <italic>vs</italic> 1.3（1.1， 1.9） ng/L］， IL-6 ［41.3（6.1， 86.5）ng/L <italic>vs</italic> 3.1（1.2， 3.9） ng/L， 56.4（7.7， 108.6）ng/L <italic>vs</italic> 38.5（6.3， 74.2） ng/L］， IL-8 ［52.9（16.8， 100.2） ng/L <italic>vs</italic> 2.9（1.9， 4.3） ng/L， 84.5（43.3， 168.7）ng/L <italic>vs</italic> 45.2（9.6， 84.3） ng/L］， IL-10 ［46.8（7.1， 136.4）ng/L <italic>vs</italic> 1.3（0.8， 7.7） ng/L， 66.7（7.9， 244.8）ng/L <italic>vs</italic> 38.2（6.8， 106.7） ng/L］ in sera and L-FABP ［63.2（4.2， 167.3）ng/L <italic>vs</italic> 4.5（2.4， 6.5） ng/L， 94.6（3.9， 268.7）ng/L <italic>vs</italic> 25.8（5.6， 103.2） ng/L］， NGAL ［18.3（10.9， 46.3）ng/L <italic>vs</italic> 3.6（1.8， 5.2） ng/L， 29.3（16.7， 85.4）ng/L <italic>vs</italic> 9.6（1.1， 25.6） ng/L］ in urine at Day 1 post-operation were higher in AKI and AKI with progression groups than those in non-AKI and AKI without progression groups （<italic>P</italic><0.05）. ROC analysis revealed that IL-6， IL-8， L-FABP and NGAL could predict the occurrence of AKI with AUC 0.79， 0.81， 0.75 and 0.74 （<italic>P</italic><0.05） respectively. Furthermore， serum IL-8 and urinary L-FABP could predict the progression of AKI with AUC 0.82 and 0.81 （<italic>P</italic><0.05）.ConclusionIL-6， IL-8， L-FABP and NGAL are obviously elevated in AKI so that they have prediction values of AKI. And marked elevations of IL-8 and L-FABP in children with AKI progression offer prediction values for AKI progression. |
| format | Article |
| id | doaj-art-53a807a88786439cb4b8a4163d72d879 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-07-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-53a807a88786439cb4b8a4163d72d8792025-08-20T02:16:11ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-07-012256757328887683Prediction of inflammation cytokines for acute kidney injury after congenital heart disease surgery in childrenSun LingXie Xing-yuanQu QiangLiu JingXiao FeiObjectiveTo explore the value of inflammation cytokines for predicting the postoperative occurrence of acute kidney injury （AKI） after surgery for congenital heart disease in children.MethodsFrom February 2018 to November 2020， 139 cases of congenital heart disease undergoing cardiopulmonary bypass surgery were recruited and divided into two groups of AKI and non-AKI. Children in AKI group were further divided into AKI with progression and AKI without progression according to whether or not renal function worsened persistently. The groups were compared with regards to the levels of interleukin （IL）-2， IL-4， IL-6， IL-8， IL-10， tumor necrosis factor-α （TNF-α）， interferon-γ （IFN-γ） in sera and liver fatty acid binding protein （L-FABP）， neutrophil gelatinase-associated lipocalin （NGAL） in urine. Correlation analysis was performed between those factors and AKI and AKI occurring predicated by area under the ROC curve （AUC）.ResultsCardiopulmonary bypass （CBP） time ［（133.6±31.5） min <italic>vs</italic> （102.8±19.8） min， 142.6（52.5， 288.6） min <italic>vs</italic> 115.7（64.8， 69.4） min］， aortic cross-clamp time ［（68.5±29.7） min <italic>vs</italic> （52.0±36.5） min， 73（56.5， 93.8） min <italic>vs</italic> 56（40.5， 72.2） min］， PICU stay ［9.7（6.4， 17.2） d <italic>vs</italic> 4.2（2.2， 7.2） d， 11.5（10.6， 15.5） d <italic>vs</italic> 5.3（4.3， 9.7） d］， hospital stay ［15.7（11.3， 19.2） d <italic>vs</italic> 9.5（8.5， 13.5） d， 21.7（15.8， 32.6） d <italic>vs</italic> 10.2（9.4， 17.6） d］， mechanical ventilation time ［5.7（1.4， 12.2） d <italic>vs</italic> 2.8（2.0， 8.9） d， 7.7（5.2， 18.7） d <italic>vs</italic> 4.8（2.2， 12.2） d］ of AKI and AKI with progression groupa were longer than those of non-AKI and AKI without progression groups （<italic>P</italic><0.05）. The levels of IL-2 ［2.4（1.1， 2.7）ng/L <italic>vs</italic> 0.9（0.5， 2.3） ng/L， 2.9（1.1， 3.6）ng/L <italic>vs</italic> 1.3（1.1， 1.9） ng/L］， IL-6 ［41.3（6.1， 86.5）ng/L <italic>vs</italic> 3.1（1.2， 3.9） ng/L， 56.4（7.7， 108.6）ng/L <italic>vs</italic> 38.5（6.3， 74.2） ng/L］， IL-8 ［52.9（16.8， 100.2） ng/L <italic>vs</italic> 2.9（1.9， 4.3） ng/L， 84.5（43.3， 168.7）ng/L <italic>vs</italic> 45.2（9.6， 84.3） ng/L］， IL-10 ［46.8（7.1， 136.4）ng/L <italic>vs</italic> 1.3（0.8， 7.7） ng/L， 66.7（7.9， 244.8）ng/L <italic>vs</italic> 38.2（6.8， 106.7） ng/L］ in sera and L-FABP ［63.2（4.2， 167.3）ng/L <italic>vs</italic> 4.5（2.4， 6.5） ng/L， 94.6（3.9， 268.7）ng/L <italic>vs</italic> 25.8（5.6， 103.2） ng/L］， NGAL ［18.3（10.9， 46.3）ng/L <italic>vs</italic> 3.6（1.8， 5.2） ng/L， 29.3（16.7， 85.4）ng/L <italic>vs</italic> 9.6（1.1， 25.6） ng/L］ in urine at Day 1 post-operation were higher in AKI and AKI with progression groups than those in non-AKI and AKI without progression groups （<italic>P</italic><0.05）. ROC analysis revealed that IL-6， IL-8， L-FABP and NGAL could predict the occurrence of AKI with AUC 0.79， 0.81， 0.75 and 0.74 （<italic>P</italic><0.05） respectively. Furthermore， serum IL-8 and urinary L-FABP could predict the progression of AKI with AUC 0.82 and 0.81 （<italic>P</italic><0.05）.ConclusionIL-6， IL-8， L-FABP and NGAL are obviously elevated in AKI so that they have prediction values of AKI. And marked elevations of IL-8 and L-FABP in children with AKI progression offer prediction values for AKI progression.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.07.007Congenital heart diseaseAcute kidney injuryInflammatory factorChild |
| spellingShingle | Sun Ling Xie Xing-yuan Qu Qiang Liu Jing Xiao Fei Prediction of inflammation cytokines for acute kidney injury after congenital heart disease surgery in children Linchuang shenzangbing zazhi Congenital heart disease Acute kidney injury Inflammatory factor Child |
| title | Prediction of inflammation cytokines for acute kidney injury after congenital heart disease surgery in children |
| title_full | Prediction of inflammation cytokines for acute kidney injury after congenital heart disease surgery in children |
| title_fullStr | Prediction of inflammation cytokines for acute kidney injury after congenital heart disease surgery in children |
| title_full_unstemmed | Prediction of inflammation cytokines for acute kidney injury after congenital heart disease surgery in children |
| title_short | Prediction of inflammation cytokines for acute kidney injury after congenital heart disease surgery in children |
| title_sort | prediction of inflammation cytokines for acute kidney injury after congenital heart disease surgery in children |
| topic | Congenital heart disease Acute kidney injury Inflammatory factor Child |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.07.007 |
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