A pilot study of intraoperative melphalan to prevent recurrent PVR: the IOMPVR study

A pilot study of intraoperative melphalan to prevent recurrent PVR: the IOMPVR study

Abstract Background Proliferative vitreoretinopathy (PVR) is a major cause of failure in cases of retinal detachment (RD) repair. Intravitreal melphalan, a known inhibitor of cellular proliferation, offers a novel therapeutic approach to reduce PVR recurrence and improve outcomes. We evaluated the s...

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Main Authors: Carlos A. Moreira-Neto, Jose S Pulido, Luca Bongiovanni de Miranda Gonçalves, Gabriel Nunes Cavalcanti, Acacio Souza Lima, José de Paula Barbosa Neto, Daniel Lavinsky, Talita Virginia Fernandes de Oliveira, Fernando Ejii Ogata, Lucas Zago Ribeiro, Luiz Fernando Teixeira, Flavia Borelli Gomes do Nascimento, Luiz H. Lima, Octaviano Jr. Magalhães, Michel Eid Farah, Maurício Maia
Format: Article
Language:English
Published: BMC 2025-05-01
Series:International Journal of Retina and Vitreous
Subjects:
Melphalan
Pars plana vitrectomy
Proliferative vitreoretinopathy
R hegmatogenous retinal detachment
Online Access:https://doi.org/10.1186/s40942-025-00675-4
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