Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis
Ferroptosis, a form of regulated cell death, has emerged as a crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by glutathione peroxidase...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024000945 |
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| author | Sadique Hussain Gaurav Gupta Moyad Shahwan Pooja Bansal Harpreet Kaur Mahamedha Deorari Kumud Pant Haider Ali Sachin Kumar Singh Venkata Sita Rama Raju Allam Keshav Raj Paudel Kamal Dua Vinoth Kumarasamy Vetriselvan Subramaniyan |
| author_facet | Sadique Hussain Gaurav Gupta Moyad Shahwan Pooja Bansal Harpreet Kaur Mahamedha Deorari Kumud Pant Haider Ali Sachin Kumar Singh Venkata Sita Rama Raju Allam Keshav Raj Paudel Kamal Dua Vinoth Kumarasamy Vetriselvan Subramaniyan |
| author_sort | Sadique Hussain |
| collection | DOAJ |
| description | Ferroptosis, a form of regulated cell death, has emerged as a crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by glutathione peroxidase 4 (GPX4), assumes an essential part in driving ferroptosis. GPX4, as the principal orchestrator of ferroptosis, has garnered significant attention across cancer, cardiovascular, and neuroscience domains over the past decade. Noteworthy investigations have elucidated the indispensable functions of ferroptosis in numerous diseases, including tumorigenesis, wherein robust ferroptosis within cells can impede tumor advancement. Recent research has underscored the complex regulatory role of non-coding RNAs (ncRNAs) in regulating the GSH-GPX4 network, thus influencing cellular susceptibility to ferroptosis. This exhaustive review endeavors to probe into the multifaceted processes by which ncRNAs control the GSH-GPX4 network in ferroptosis. Specifically, we delve into the functions of miRNAs, lncRNAs, and circRNAs in regulating GPX4 expression and impacting cellular susceptibility to ferroptosis. Moreover, we discuss the clinical implications of dysregulated interactions between ncRNAs and GPX4 in several conditions, underscoring their capacity as viable targets for therapeutic intervention. Additionally, the review explores emerging strategies aimed at targeting ncRNAs to modulate the GSH-GPX4 pathway and manipulate ferroptosis for therapeutic advantage. A comprehensive understanding of these intricate regulatory networks furnishes insights into innovative therapeutic avenues for diseases associated with perturbed ferroptosis, thereby laying the groundwork for therapeutic interventions targeting ncRNAs in ferroptosis-related pathological conditions. |
| format | Article |
| id | doaj-art-53a4becffc2e41b29ef7bb3bce0e3392 |
| institution | OA Journals |
| issn | 2468-0540 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj-art-53a4becffc2e41b29ef7bb3bce0e33922025-08-20T02:38:21ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-12-01941222123410.1016/j.ncrna.2024.05.007Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosisSadique Hussain0Gaurav Gupta1Moyad Shahwan2Pooja Bansal3Harpreet Kaur4Mahamedha Deorari5Kumud Pant6Haider Ali7Sachin Kumar Singh8Venkata Sita Rama Raju Allam9Keshav Raj Paudel10Kamal Dua11Vinoth Kumarasamy12Vetriselvan Subramaniyan13Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, IndiaCentre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, 346, United Arab Emirates; Corresponding author. Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia.Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, 346, United Arab Emirates; Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, 346, United Arab EmiratesDepartment of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bengaluru, Karnataka, 560069, India; Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, IndiaSchool of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India; Department of Health & Allied Sciences, Arka Jain University, Jamshedpur, Jharkhand, 831001, IndiaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, IndiaGraphic Era (Deemed to be University), Clement Town, Dehradun, 248002, India; Graphic Era Hill University, Clement Town, Dehradun, 248002, IndiaCentre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; Department of Pharmacology, Kyrgyz State Medical College, Bishkek, KyrgyzstanSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, AustraliaDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, SwedenCentre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW, 2007, AustraliaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, P.O. Box: 123 Broadway, Ultimo, NSW, 2007, AustraliaDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000, Kuala Lumpur, Malaysia; Corresponding author.Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia; Correspondingauthor.Ferroptosis, a form of regulated cell death, has emerged as a crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by glutathione peroxidase 4 (GPX4), assumes an essential part in driving ferroptosis. GPX4, as the principal orchestrator of ferroptosis, has garnered significant attention across cancer, cardiovascular, and neuroscience domains over the past decade. Noteworthy investigations have elucidated the indispensable functions of ferroptosis in numerous diseases, including tumorigenesis, wherein robust ferroptosis within cells can impede tumor advancement. Recent research has underscored the complex regulatory role of non-coding RNAs (ncRNAs) in regulating the GSH-GPX4 network, thus influencing cellular susceptibility to ferroptosis. This exhaustive review endeavors to probe into the multifaceted processes by which ncRNAs control the GSH-GPX4 network in ferroptosis. Specifically, we delve into the functions of miRNAs, lncRNAs, and circRNAs in regulating GPX4 expression and impacting cellular susceptibility to ferroptosis. Moreover, we discuss the clinical implications of dysregulated interactions between ncRNAs and GPX4 in several conditions, underscoring their capacity as viable targets for therapeutic intervention. Additionally, the review explores emerging strategies aimed at targeting ncRNAs to modulate the GSH-GPX4 pathway and manipulate ferroptosis for therapeutic advantage. A comprehensive understanding of these intricate regulatory networks furnishes insights into innovative therapeutic avenues for diseases associated with perturbed ferroptosis, thereby laying the groundwork for therapeutic interventions targeting ncRNAs in ferroptosis-related pathological conditions.http://www.sciencedirect.com/science/article/pii/S2468054024000945FerroptosisncRNAsCancerGSH-GPX4Cell death |
| spellingShingle | Sadique Hussain Gaurav Gupta Moyad Shahwan Pooja Bansal Harpreet Kaur Mahamedha Deorari Kumud Pant Haider Ali Sachin Kumar Singh Venkata Sita Rama Raju Allam Keshav Raj Paudel Kamal Dua Vinoth Kumarasamy Vetriselvan Subramaniyan Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis Non-coding RNA Research Ferroptosis ncRNAs Cancer GSH-GPX4 Cell death |
| title | Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis |
| title_full | Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis |
| title_fullStr | Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis |
| title_full_unstemmed | Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis |
| title_short | Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis |
| title_sort | non coding rna a key regulator in the glutathione gpx4 pathway of ferroptosis |
| topic | Ferroptosis ncRNAs Cancer GSH-GPX4 Cell death |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024000945 |
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