Storage of Verbal Associations Is Sufficient to Activate the Left Medial Temporal Lobe
Neuroimaging studies have shown that memory encoding activates the medial temporal lobe (MTL). Many believe that these activations are related to novelty but it remains unproven which is critical - novelty detection or the rich associative encoding it triggers. We examined MTL activation during verb...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/1999/892074 |
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| _version_ | 1850224842841784320 |
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| author | Andrew R. Mayes Patricia A. Gooding Nicola M. Hunkin Julia A. Nunn Lloyd J. Gregory Michael J. Brammer Edward T. Bullmore Vincent Giampietro Rob Van Eijk Amanda K. Nicholas Steve C. R. Williams |
| author_facet | Andrew R. Mayes Patricia A. Gooding Nicola M. Hunkin Julia A. Nunn Lloyd J. Gregory Michael J. Brammer Edward T. Bullmore Vincent Giampietro Rob Van Eijk Amanda K. Nicholas Steve C. R. Williams |
| author_sort | Andrew R. Mayes |
| collection | DOAJ |
| description | Neuroimaging studies have shown that memory encoding activates the medial temporal lobe (MTL). Many believe that these activations are related to novelty but it remains unproven which is critical - novelty detection or the rich associative encoding it triggers. We examined MTL activation during verbal associative encoding using functional magnetic resonance imaging. First, associative encoding activated left posterior MTL more than single word encoding even though novelty detection was matched, indicating not only that associative encoding activates the MTL particularly strongly, but also that activation does not require novelty detection. Moreover, it remains to be convincingly shown that novelty detection alone does produce such activation. Second, repetitive associative encoding produced less MTL activation than initial associative encoding, indicating that priming of associative information reduces MTL activation. Third, re-encoding familiar associations in a well-established way had a minimal effect on both memory and MTL activation, indicating that MTL activation reflects storage of associations, not merely their initial representation. |
| format | Article |
| id | doaj-art-53a2a4ed18b54459a7a56c00fdf4830e |
| institution | OA Journals |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-53a2a4ed18b54459a7a56c00fdf4830e2025-08-20T02:05:31ZengWileyBehavioural Neurology0953-41801875-85841999-01-0111316317210.1155/1999/892074Storage of Verbal Associations Is Sufficient to Activate the Left Medial Temporal LobeAndrew R. Mayes0Patricia A. Gooding1Nicola M. Hunkin2Julia A. Nunn3Lloyd J. Gregory4Michael J. Brammer5Edward T. Bullmore6Vincent Giampietro7Rob Van Eijk8Amanda K. Nicholas9Steve C. R. Williams10Department of Clinical Neurology, University of Sheffield, Sheffield S10 2JF, UKDepartment of Psychology, University of Strathclyde, Glasgow G1 1XQ, UKDepartment of Clinical Neurology, University of Sheffield, Sheffield S10 2JF, UKDepartment of Clinical Neurology, University of Sheffield, Sheffield S10 2JF, UKNeuroimaging Unit, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UKBrain Image Analysis Unit, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UKBrain Image Analysis Unit, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UKBrain Image Analysis Unit, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UKDepartment of Psychology, University of Strathclyde, Glasgow G1 1XQ, UKDepartment of Clinical Neurology, University of Sheffield, Sheffield S10 2JF, UKNeuroimaging Unit, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UKNeuroimaging studies have shown that memory encoding activates the medial temporal lobe (MTL). Many believe that these activations are related to novelty but it remains unproven which is critical - novelty detection or the rich associative encoding it triggers. We examined MTL activation during verbal associative encoding using functional magnetic resonance imaging. First, associative encoding activated left posterior MTL more than single word encoding even though novelty detection was matched, indicating not only that associative encoding activates the MTL particularly strongly, but also that activation does not require novelty detection. Moreover, it remains to be convincingly shown that novelty detection alone does produce such activation. Second, repetitive associative encoding produced less MTL activation than initial associative encoding, indicating that priming of associative information reduces MTL activation. Third, re-encoding familiar associations in a well-established way had a minimal effect on both memory and MTL activation, indicating that MTL activation reflects storage of associations, not merely their initial representation.http://dx.doi.org/10.1155/1999/892074 |
| spellingShingle | Andrew R. Mayes Patricia A. Gooding Nicola M. Hunkin Julia A. Nunn Lloyd J. Gregory Michael J. Brammer Edward T. Bullmore Vincent Giampietro Rob Van Eijk Amanda K. Nicholas Steve C. R. Williams Storage of Verbal Associations Is Sufficient to Activate the Left Medial Temporal Lobe Behavioural Neurology |
| title | Storage of Verbal Associations Is Sufficient to Activate the Left Medial Temporal Lobe |
| title_full | Storage of Verbal Associations Is Sufficient to Activate the Left Medial Temporal Lobe |
| title_fullStr | Storage of Verbal Associations Is Sufficient to Activate the Left Medial Temporal Lobe |
| title_full_unstemmed | Storage of Verbal Associations Is Sufficient to Activate the Left Medial Temporal Lobe |
| title_short | Storage of Verbal Associations Is Sufficient to Activate the Left Medial Temporal Lobe |
| title_sort | storage of verbal associations is sufficient to activate the left medial temporal lobe |
| url | http://dx.doi.org/10.1155/1999/892074 |
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