Pre-transplant T-cell clonal analysis identifies CD8+ donor reactive clones that contribute to kidney transplant rejection

Pre-transplant T-cell clonal analysis identifies CD8+ donor reactive clones that contribute to kidney transplant rejection

IntroductionResponses to allogeneic human leukocyte antigen (HLA) molecules limit the survival of transplanted organs. The changes in T-cell alloreactivity that contribute to this process, however, are not fully understood. We defined a set of donor reactive T-cell clones (DRTC) with the goal to elu...

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Bibliographic Details
Main Authors: Jes M. Sanders, Barbara L. Banbury, Erika L. Schumacher, Jie He, Yuvaraj Sambandam, Paul A. Fields, Lorenzo Gallon, James M. Mathew, Joseph R. Leventhal
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
kidney transplant rejection
alloreactivity
T-cell receptor sequencing
T-cell mediated rejection
mechanisms of rejection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1516772/full
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