Supplementation with Red Palm Oil Increases β-Carotene and Vitamin A Blood Levels in Patients with Cystic Fibrosis
Patients with cystic fibrosis (CF) show decreased plasma concentrations of antioxidants due to malabsorption of lipid soluble vitamins and consumption by chronic pulmonary inflammation. β-Carotene is a major source of retinol and therefore is of particular significance in CF. The aim of this study w...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/817127 |
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| author | Olaf Sommerburg Silke De Spirt Annett Mattern Cornelia Joachim Claus-Dieter Langhans Kalanithi Nesaretnam Werner Siems Wilhelm Stahl Marcus A. Mall |
| author_facet | Olaf Sommerburg Silke De Spirt Annett Mattern Cornelia Joachim Claus-Dieter Langhans Kalanithi Nesaretnam Werner Siems Wilhelm Stahl Marcus A. Mall |
| author_sort | Olaf Sommerburg |
| collection | DOAJ |
| description | Patients with cystic fibrosis (CF) show decreased plasma concentrations of antioxidants due to malabsorption of lipid soluble vitamins and consumption by chronic pulmonary inflammation. β-Carotene is a major source of retinol and therefore is of particular significance in CF. The aim of this study was to investigate the effect of daily intake of red palm oil (RPO) containing high amounts of β-carotene on the antioxidant levels in CF patients. Sixteen subjects were recruited and instructed to enrich their food with 2 to 3 tablespoons of RPO (~1.5 mg of β-carotene) daily over 8 weeks. Carotenoids, retinol, and α-tocopherol were measured in plasma at baseline and after intervention. In addition β-carotene, lycopene, α-tocopherol, and vitamin C were measured in buccal mucosa cells (BMC) to determine the influence of RPO on antioxidant tissue levels. Eleven subjects completed the study properly. Plasma β-carotene, retinol, and α-carotene of these patients increased, but plasma concentrations of other carotenoids and α-tocopherol as well as concentrations of β-carotene, lycopene, α-tocopherol, and vitamin C in BMC remained unchanged. Since RPO on a daily basis did not show negative side effects the data suggest that RPO may be used to elevate plasma β-carotene in CF. |
| format | Article |
| id | doaj-art-539c11e1b6dd480185312260a7d8cd45 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-539c11e1b6dd480185312260a7d8cd452025-08-20T03:36:42ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/817127817127Supplementation with Red Palm Oil Increases β-Carotene and Vitamin A Blood Levels in Patients with Cystic FibrosisOlaf Sommerburg0Silke De Spirt1Annett Mattern2Cornelia Joachim3Claus-Dieter Langhans4Kalanithi Nesaretnam5Werner Siems6Wilhelm Stahl7Marcus A. Mall8Division of Pediatric Pulmonology & Allergy and Cystic Fibrosis Centre, Department of Pediatrics III, Children’s Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, GermanyInstitute of Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich-Heine-University Dusseldorf, 40001 Dusseldorf, GermanyDivision of Pediatric Pulmonology & Allergy and Cystic Fibrosis Centre, Department of Pediatrics III, Children’s Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, GermanyDivision of Pediatric Pulmonology & Allergy and Cystic Fibrosis Centre, Department of Pediatrics III, Children’s Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, GermanyDivision of Metabolic Diseases and Newborn Screening Centre, Department of Paediatrics I, Children’s Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, GermanyProduct Development and Advisory Services, Malaysian Palm Oil Board (MPOB), 6 Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, MalaysiaResearch Institute of Physiotherapy and Gerontology, KortexMed Institute of Medical Education, Hindenburgring 12a, 38667 Bad Harzburg, GermanyInstitute of Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich-Heine-University Dusseldorf, 40001 Dusseldorf, GermanyDivision of Pediatric Pulmonology & Allergy and Cystic Fibrosis Centre, Department of Pediatrics III, Children’s Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, GermanyPatients with cystic fibrosis (CF) show decreased plasma concentrations of antioxidants due to malabsorption of lipid soluble vitamins and consumption by chronic pulmonary inflammation. β-Carotene is a major source of retinol and therefore is of particular significance in CF. The aim of this study was to investigate the effect of daily intake of red palm oil (RPO) containing high amounts of β-carotene on the antioxidant levels in CF patients. Sixteen subjects were recruited and instructed to enrich their food with 2 to 3 tablespoons of RPO (~1.5 mg of β-carotene) daily over 8 weeks. Carotenoids, retinol, and α-tocopherol were measured in plasma at baseline and after intervention. In addition β-carotene, lycopene, α-tocopherol, and vitamin C were measured in buccal mucosa cells (BMC) to determine the influence of RPO on antioxidant tissue levels. Eleven subjects completed the study properly. Plasma β-carotene, retinol, and α-carotene of these patients increased, but plasma concentrations of other carotenoids and α-tocopherol as well as concentrations of β-carotene, lycopene, α-tocopherol, and vitamin C in BMC remained unchanged. Since RPO on a daily basis did not show negative side effects the data suggest that RPO may be used to elevate plasma β-carotene in CF.http://dx.doi.org/10.1155/2015/817127 |
| spellingShingle | Olaf Sommerburg Silke De Spirt Annett Mattern Cornelia Joachim Claus-Dieter Langhans Kalanithi Nesaretnam Werner Siems Wilhelm Stahl Marcus A. Mall Supplementation with Red Palm Oil Increases β-Carotene and Vitamin A Blood Levels in Patients with Cystic Fibrosis Mediators of Inflammation |
| title | Supplementation with Red Palm Oil Increases β-Carotene and Vitamin A Blood Levels in Patients with Cystic Fibrosis |
| title_full | Supplementation with Red Palm Oil Increases β-Carotene and Vitamin A Blood Levels in Patients with Cystic Fibrosis |
| title_fullStr | Supplementation with Red Palm Oil Increases β-Carotene and Vitamin A Blood Levels in Patients with Cystic Fibrosis |
| title_full_unstemmed | Supplementation with Red Palm Oil Increases β-Carotene and Vitamin A Blood Levels in Patients with Cystic Fibrosis |
| title_short | Supplementation with Red Palm Oil Increases β-Carotene and Vitamin A Blood Levels in Patients with Cystic Fibrosis |
| title_sort | supplementation with red palm oil increases β carotene and vitamin a blood levels in patients with cystic fibrosis |
| url | http://dx.doi.org/10.1155/2015/817127 |
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