Age-related changes in myocardial deformation and arterial stiffness in hypertensive males
In terms of the general aging of population the role of senescence in the vascular and cardiac remodeling development remains controversial. The ways the ventricular and arterial stiffening affects the myocardial functioning are still unclear. Objective. The aim of this study was to evaluate the...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2016-12-01
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| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/85487/83144 |
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| Summary: | In terms of the general aging of population the role of senescence in the vascular and cardiac remodeling development remains controversial. The ways the ventricular and arterial stiffening affects the myocardial functioning are still unclear.
Objective. The aim of this study was to evaluate the impact of aging on myocardial deformation and arterial stiffness in hypertensive men using aortic pulse wave velocity (aoPWV) and speckle tracking echocardiography.
Materials and Methods. 32 men with arterial hypertension stage II and 12 healthy males from 45 to 72 years were included into this study. Aortic stiffness was evaluated with the use of BPLab Vasotens System. Transthoracic echocardiography was performed using My Lab 50 equipment (Esaote, Italy). The patients with hypertension and healthy individuals from the control group were divided into 2 groups according their age.
Results. ASI significantly correlated with age (r=0.26, p<0.05), PP (r=0.22, p< 0.05), aoPWV (r=0.16, p<0.05), AIx (r=0.16, p=0.002). PPA appeared related to BP (r= 0.27, p<0.05 for SBP with PPA). Global longitudinal strain (GLS) becomes significantly reduced in hypertensive patients compared to the control group. It was markedly diminished in both groups over 55 years. GLS correlated with aoPWV (r=0.26, p<0.05). Circumferential and radial strain at the basal and the apical LV segments did not show significant difference in groups divided by age.
Conclusions. The present study demonstrates the additional impact of aging on the development of both cardiac and vascular remodeling, leading to myocardial longitudinal strain disorders and an enhanced arterial stiffness. At the basis of revealed correlations aoPWV and global longitudinal strain may be considered also as the marker of vascular aging in hypertensive men and in general population. |
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| ISSN: | 2306-4145 2310-1210 |