Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons
The emergence of novel avian influenza reassortants in wild birds in recent years is a public health concern. However, the viruses that circulate in migratory birds are not fully understood. In this study, we summarized and categorized global H11 avian influenza viruses and reported that waterfowl a...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2398641 |
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| _version_ | 1850111916719996928 |
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| author | Jinyan Shen Hong Zhang Xiaohong Sun Yaping Zhang Mengjing Wang Mengdi Guan Lili Liu Wenxi Li Hongke Xu Yujiao Xie Anran Ren Fengyang Cao Wenqiang Liu Guohua Deng Jing Guo Xuyong Li |
| author_facet | Jinyan Shen Hong Zhang Xiaohong Sun Yaping Zhang Mengjing Wang Mengdi Guan Lili Liu Wenxi Li Hongke Xu Yujiao Xie Anran Ren Fengyang Cao Wenqiang Liu Guohua Deng Jing Guo Xuyong Li |
| author_sort | Jinyan Shen |
| collection | DOAJ |
| description | The emergence of novel avian influenza reassortants in wild birds in recent years is a public health concern. However, the viruses that circulate in migratory birds are not fully understood. In this study, we summarized and categorized global H11 avian influenza viruses and reported that waterfowl and shorebirds are the major reservoirs of the identified H11 viruses. The surveillance data of the 35,749 faecal samples collected from wild bird habitats in eastern China over the past seven years revealed a low prevalence of H11 viruses in birds, with a positive rate of 0.067% (24 isolates). The phylogenetic analysis of the twenty viruses indicated that H11 viruses have undergone complex reassortment with viruses circulating in waterfowl and shorebirds. These tested viruses do not acquire mammalian adaptive mutations in their genomes and preferentially bind to avian-type receptors. Experimental infection studies demonstrated that the two tested H11N9 viruses of wild bird origin replicated and transmitted more efficiently in ducks than in chickens, whereas the pigeon H11N2 virus isolated from a live poultry market was more adapted to replicate in chickens than in ducks. In addition, some H11 isolates replicated efficiently in mice and caused body weight loss but were not lethal. Our study revealed the role of waterfowl and shorebirds in the ecology and evolution of H11 viruses and the potential risk of introducing circulating H11 viruses into ducks or chickens, further emphasizing the importance of avian influenza surveillance at the interface of migratory birds and poultry. |
| format | Article |
| id | doaj-art-5396ce46cf474a7da9c86c9f3595f3e6 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-5396ce46cf474a7da9c86c9f3595f3e62025-08-20T02:37:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2398641Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeonsJinyan Shen0Hong Zhang1Xiaohong Sun2Yaping Zhang3Mengjing Wang4Mengdi Guan5Lili Liu6Wenxi Li7Hongke Xu8Yujiao Xie9Anran Ren10Fengyang Cao11Wenqiang Liu12Guohua Deng13Jing Guo14Xuyong Li15College of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaHarbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, State Key Laboratory for Animal Disease Control and Prevention, Harbin, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaHarbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, State Key Laboratory for Animal Disease Control and Prevention, Harbin, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng, People’s Republic of ChinaThe emergence of novel avian influenza reassortants in wild birds in recent years is a public health concern. However, the viruses that circulate in migratory birds are not fully understood. In this study, we summarized and categorized global H11 avian influenza viruses and reported that waterfowl and shorebirds are the major reservoirs of the identified H11 viruses. The surveillance data of the 35,749 faecal samples collected from wild bird habitats in eastern China over the past seven years revealed a low prevalence of H11 viruses in birds, with a positive rate of 0.067% (24 isolates). The phylogenetic analysis of the twenty viruses indicated that H11 viruses have undergone complex reassortment with viruses circulating in waterfowl and shorebirds. These tested viruses do not acquire mammalian adaptive mutations in their genomes and preferentially bind to avian-type receptors. Experimental infection studies demonstrated that the two tested H11N9 viruses of wild bird origin replicated and transmitted more efficiently in ducks than in chickens, whereas the pigeon H11N2 virus isolated from a live poultry market was more adapted to replicate in chickens than in ducks. In addition, some H11 isolates replicated efficiently in mice and caused body weight loss but were not lethal. Our study revealed the role of waterfowl and shorebirds in the ecology and evolution of H11 viruses and the potential risk of introducing circulating H11 viruses into ducks or chickens, further emphasizing the importance of avian influenza surveillance at the interface of migratory birds and poultry.https://www.tandfonline.com/doi/10.1080/22221751.2024.2398641Avian influenza virusesH11migratory birdsepidemiologypoultry |
| spellingShingle | Jinyan Shen Hong Zhang Xiaohong Sun Yaping Zhang Mengjing Wang Mengdi Guan Lili Liu Wenxi Li Hongke Xu Yujiao Xie Anran Ren Fengyang Cao Wenqiang Liu Guohua Deng Jing Guo Xuyong Li Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons Emerging Microbes and Infections Avian influenza viruses H11 migratory birds epidemiology poultry |
| title | Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons |
| title_full | Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons |
| title_fullStr | Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons |
| title_full_unstemmed | Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons |
| title_short | Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons |
| title_sort | evolution and biological characteristics of h11 avian influenza viruses isolated from migratory birds and pigeons |
| topic | Avian influenza viruses H11 migratory birds epidemiology poultry |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2398641 |
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