Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions
Two cases of women in their thirties with past histories of atopic dermatitis and allergic rhinitis developed a low grade fever, followed by a butterfly-shaped erythema, swelling of their fingers, and polyarthralgia. Despite such symptoms that overlap with those of systemic lupus erythematosus (SLE)...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/703281 |
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| author | Itsuro Kazama Naoko Sasagawa Toshiyuki Nakajima |
| author_facet | Itsuro Kazama Naoko Sasagawa Toshiyuki Nakajima |
| author_sort | Itsuro Kazama |
| collection | DOAJ |
| description | Two cases of women in their thirties with past histories of atopic dermatitis and allergic rhinitis developed a low grade fever, followed by a butterfly-shaped erythema, swelling of their fingers, and polyarthralgia. Despite such symptoms that overlap with those of systemic lupus erythematosus (SLE), the diagnostic criteria for SLE were not fulfilled. Due to positive results for human parvovirus B19 (HPV-B19) IgM antibodies in the serum, diagnoses of HPV-B19 infection were made in both cases. Although acetaminophen failed to improve their deteriorating symptoms, a nonsteroidal anti-inflammatory drug (NSAID), loxoprofen, completely removed the symptoms immediately after the administration. In those cases, since the patients were predisposed to atopic disorders, an increased immunological response based on the lymphocyte hypersensitivity was likely to be involved in the pathogenesis. The immunomodulatory property of NSAID was thought to repress such lymphocyte activity and thus provided a rapid and sustained remission of the disease. |
| format | Article |
| id | doaj-art-5394fcb076fa414aadaeb75960d40fc3 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-5394fcb076fa414aadaeb75960d40fc32025-08-20T03:36:42ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/703281703281Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic PredispositionsItsuro Kazama0Naoko Sasagawa1Toshiyuki Nakajima2Department of Physiology I, Tohoku University Graduate School of Medicine, Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartment of Internal Medicine, Iwakiri Hospital, Miyagino-ku, Sendai, Miyagi 983-0821, JapanDepartment of Internal Medicine, Iwakiri Hospital, Miyagino-ku, Sendai, Miyagi 983-0821, JapanTwo cases of women in their thirties with past histories of atopic dermatitis and allergic rhinitis developed a low grade fever, followed by a butterfly-shaped erythema, swelling of their fingers, and polyarthralgia. Despite such symptoms that overlap with those of systemic lupus erythematosus (SLE), the diagnostic criteria for SLE were not fulfilled. Due to positive results for human parvovirus B19 (HPV-B19) IgM antibodies in the serum, diagnoses of HPV-B19 infection were made in both cases. Although acetaminophen failed to improve their deteriorating symptoms, a nonsteroidal anti-inflammatory drug (NSAID), loxoprofen, completely removed the symptoms immediately after the administration. In those cases, since the patients were predisposed to atopic disorders, an increased immunological response based on the lymphocyte hypersensitivity was likely to be involved in the pathogenesis. The immunomodulatory property of NSAID was thought to repress such lymphocyte activity and thus provided a rapid and sustained remission of the disease.http://dx.doi.org/10.1155/2012/703281 |
| spellingShingle | Itsuro Kazama Naoko Sasagawa Toshiyuki Nakajima Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions Case Reports in Medicine |
| title | Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions |
| title_full | Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions |
| title_fullStr | Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions |
| title_full_unstemmed | Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions |
| title_short | Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions |
| title_sort | complete remission of human parvovirus b19 associated symptoms by loxoprofen in patients with atopic predispositions |
| url | http://dx.doi.org/10.1155/2012/703281 |
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