DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis

DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis

Abstract Background Pulmonary fibrosis (PF) is a progressive and difficult-to-heal lung disease that poses a significant threat to human life and health. This study aimed to investigate the potential pathological mechanisms of PF and to identify new avenues for the treatment of PF. Methods Clinical...

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Bibliographic Details
Main Authors: Juan Wang, Zhenkun Xia, Bei Qing, Ying Chen, Linguo Gu, Hongzuo Chen, Zhenglian Ge, Yunchang Yuan
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Medicine
Subjects:
Pulmonary fibrosis
DsbA-L
TGF-β1/SMAD3 signaling
M2 macrophage polarization
AKT1
NLRP3
Online Access:https://doi.org/10.1186/s10020-024-00983-9
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