A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease
Abstract Background In recent months, Bordetella pertussis has reappeared after maintaining a low rate for many years. Although pertussis is usually characterized by a favorable course, several factors can contribute to the severity of the disease, such as mixed respiratory infections. In this study...
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| Language: | English |
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BMC
2025-01-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-025-01865-4 |
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| author | Rossana Scutari Giulia Linardos Stefania Ranno Mara Pisani Anna Chiara Vittucci Luana Coltella Luna Colagrossi Velia Chiara Di Maio Annamaria Sisto Livia Mancinelli Simona Landi Sebastian Cristaldi Massimiliano Raponi Paola Bernaschi Alberto Villani Cristina Russo Carlo Federico Perno |
| author_facet | Rossana Scutari Giulia Linardos Stefania Ranno Mara Pisani Anna Chiara Vittucci Luana Coltella Luna Colagrossi Velia Chiara Di Maio Annamaria Sisto Livia Mancinelli Simona Landi Sebastian Cristaldi Massimiliano Raponi Paola Bernaschi Alberto Villani Cristina Russo Carlo Federico Perno |
| author_sort | Rossana Scutari |
| collection | DOAJ |
| description | Abstract Background In recent months, Bordetella pertussis has reappeared after maintaining a low rate for many years. Although pertussis is usually characterized by a favorable course, several factors can contribute to the severity of the disease, such as mixed respiratory infections. In this study, we evaluate B.pertussis cases observed in the pediatric population followed at the Bambino Gesù Children's Hospital and analyzed the potential impact of co-infections in relation to disease severity. Methods From January to May 2024, a total of 1,151 children and adolescents (both inpatients and outpatients) were screened for the presence of respiratory pathogens, including B.pertussis, with clinically relevant respiratory symptoms. Results Among the 1,151 patients screened, 66 tested positive for B.pertussis. Fourteen patients had respiratory failure, and six of them required intensive care unit (ICU) admission, while 52 had mild infection. 23.3% of patients had B.pertussis alone, while 76.7% had co-infections (including 5 patients admitted to the ICU). A higher co-infection rate was observed in patients with respiratory failure than in those without failure (92.9% vs. 69.0%, p-value:0.041). Rhinovirus, Metapneumovirus and Parainfluenza-virus were the most prevalent in our pediatric population. Co-infections of human bocavirus with B.pertussis were observed exclusively in patients with respiratory failure. Conclusions Our results highlighted an increase in B.pertussis cases from January to May 2024, reaching a peak of cases in the month of May. This study shows a high rate of B.pertussis co-infection, and a trend toward association between B.pertussis and specific viruses, that might play a role in increasing disease severity. |
| format | Article |
| id | doaj-art-5393db0ac0b44dfd83ec6487d7399cbf |
| institution | Kabale University |
| issn | 1824-7288 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj-art-5393db0ac0b44dfd83ec6487d7399cbf2025-01-26T12:45:08ZengBMCItalian Journal of Pediatrics1824-72882025-01-015111710.1186/s13052-025-01865-4A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis diseaseRossana Scutari0Giulia Linardos1Stefania Ranno2Mara Pisani3Anna Chiara Vittucci4Luana Coltella5Luna Colagrossi6Velia Chiara Di Maio7Annamaria Sisto8Livia Mancinelli9Simona Landi10Sebastian Cristaldi11Massimiliano Raponi12Paola Bernaschi13Alberto Villani14Cristina Russo15Carlo Federico Perno16Unit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSHospital University Pediatrics Clinical Area, Bambino Gesù Children’s Hospital IRCCSHospital University Pediatrics Clinical Area, Bambino Gesù Children’s Hospital IRCCSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSHospital University Pediatrics Clinical Area, Bambino Gesù Children’s Hospital IRCCSMedical Direction, Bambino Gesù Children’s Hospital, IRCCSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSHospital University Pediatrics Clinical Area, Bambino Gesù Children’s Hospital IRCCSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children’s Hospital, IRCSSAbstract Background In recent months, Bordetella pertussis has reappeared after maintaining a low rate for many years. Although pertussis is usually characterized by a favorable course, several factors can contribute to the severity of the disease, such as mixed respiratory infections. In this study, we evaluate B.pertussis cases observed in the pediatric population followed at the Bambino Gesù Children's Hospital and analyzed the potential impact of co-infections in relation to disease severity. Methods From January to May 2024, a total of 1,151 children and adolescents (both inpatients and outpatients) were screened for the presence of respiratory pathogens, including B.pertussis, with clinically relevant respiratory symptoms. Results Among the 1,151 patients screened, 66 tested positive for B.pertussis. Fourteen patients had respiratory failure, and six of them required intensive care unit (ICU) admission, while 52 had mild infection. 23.3% of patients had B.pertussis alone, while 76.7% had co-infections (including 5 patients admitted to the ICU). A higher co-infection rate was observed in patients with respiratory failure than in those without failure (92.9% vs. 69.0%, p-value:0.041). Rhinovirus, Metapneumovirus and Parainfluenza-virus were the most prevalent in our pediatric population. Co-infections of human bocavirus with B.pertussis were observed exclusively in patients with respiratory failure. Conclusions Our results highlighted an increase in B.pertussis cases from January to May 2024, reaching a peak of cases in the month of May. This study shows a high rate of B.pertussis co-infection, and a trend toward association between B.pertussis and specific viruses, that might play a role in increasing disease severity.https://doi.org/10.1186/s13052-025-01865-4Bordetella pertussisWhooping coughCo-infectionsInfantsEpidemiologyPertussis disease |
| spellingShingle | Rossana Scutari Giulia Linardos Stefania Ranno Mara Pisani Anna Chiara Vittucci Luana Coltella Luna Colagrossi Velia Chiara Di Maio Annamaria Sisto Livia Mancinelli Simona Landi Sebastian Cristaldi Massimiliano Raponi Paola Bernaschi Alberto Villani Cristina Russo Carlo Federico Perno A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease Italian Journal of Pediatrics Bordetella pertussis Whooping cough Co-infections Infants Epidemiology Pertussis disease |
| title | A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease |
| title_full | A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease |
| title_fullStr | A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease |
| title_full_unstemmed | A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease |
| title_short | A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease |
| title_sort | new epidemic wave of bordetella pertussis in paediatric population impact and role of co infections in pertussis disease |
| topic | Bordetella pertussis Whooping cough Co-infections Infants Epidemiology Pertussis disease |
| url | https://doi.org/10.1186/s13052-025-01865-4 |
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