Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled TMEM16A Potentiator GDC‐6988

Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled TMEM16A Potentiator GDC‐6988

ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regio...

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Main Authors: Rui Zhu, Ian Sorrell, Fang Ma, Miaoran Ning, Yoen‐Ju Son, Gaohong She, Tom De Bruyn, Joshua Galanter, Nastya Kassir, Ryan Owen, Masoud Jamei, Iain Gardner, Yuan Chen
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.70027
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