Role of IL-37 and Dectin-1 during Toxoplasmosis
Toxoplasmosis is a parasitic infection that triggers immune cells to produce cytokines and inflammatory mediators that are responsible for abnormal or aborted immune responses. This study highlights the evaluation of the Dectin-1 receptor and cytokine IL-37 in the serum of 80 patients who had misca...
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University of Baghdad, College of Science for Women
2023-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7618 |
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| author | Zahra’a A. Ahmed Ekhlas M. Idan Naksheen M. Ardalan |
| author_facet | Zahra’a A. Ahmed Ekhlas M. Idan Naksheen M. Ardalan |
| author_sort | Zahra’a A. Ahmed |
| collection | DOAJ |
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Toxoplasmosis is a parasitic infection that triggers immune cells to produce cytokines and inflammatory mediators that are responsible for abnormal or aborted immune responses. This study highlights the evaluation of the Dectin-1 receptor and cytokine IL-37 in the serum of 80 patients who had miscarried in the first trimester and were infected with toxoplasmosis, as well as 40 pregnant women in the first trimester who had a successful pregnancy (control groups). The serum was first screened for the T. gondii IgM and IgG antibodies by an enzyme-linked immunosorbent assay (ELISA) and then the serum levels of IL-37 and Dectin-1 were determined. The results showed that the serum level of Dectin-1 was significantly increased in anti-Toxoplasma IgM and IgG patients 362.382 ± 45.937 and 361.916 ± 71.993 ng/L respectively, as compared with the controls 155.702 ± 26.356 ng/L, while the serum level of IL-37 was convergent in anti-Toxoplasma IgM and IgG patients and controls 52.666 ± 4.272, 66.808 ± 9.132, and 51.984 ± 3.619 ng/L respectively, with no significant differences. In conclusion, Dectin-1 receptor may play a role in pregnancy loss, especially in T. gondii infection.
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| format | Article |
| id | doaj-art-5390f14d2bbb42ad8a27e32e9a28da52 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-5390f14d2bbb42ad8a27e32e9a28da522025-08-20T02:55:02ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862023-06-0120310.21123/bsj.2022.7618Role of IL-37 and Dectin-1 during ToxoplasmosisZahra’a A. Ahmed0Ekhlas M. Idan1Naksheen M. Ardalan2Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq.Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq.Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq. Toxoplasmosis is a parasitic infection that triggers immune cells to produce cytokines and inflammatory mediators that are responsible for abnormal or aborted immune responses. This study highlights the evaluation of the Dectin-1 receptor and cytokine IL-37 in the serum of 80 patients who had miscarried in the first trimester and were infected with toxoplasmosis, as well as 40 pregnant women in the first trimester who had a successful pregnancy (control groups). The serum was first screened for the T. gondii IgM and IgG antibodies by an enzyme-linked immunosorbent assay (ELISA) and then the serum levels of IL-37 and Dectin-1 were determined. The results showed that the serum level of Dectin-1 was significantly increased in anti-Toxoplasma IgM and IgG patients 362.382 ± 45.937 and 361.916 ± 71.993 ng/L respectively, as compared with the controls 155.702 ± 26.356 ng/L, while the serum level of IL-37 was convergent in anti-Toxoplasma IgM and IgG patients and controls 52.666 ± 4.272, 66.808 ± 9.132, and 51.984 ± 3.619 ng/L respectively, with no significant differences. In conclusion, Dectin-1 receptor may play a role in pregnancy loss, especially in T. gondii infection. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7618C-type lectin receptor, Cytokine, Dectin-1, IL-37, Miscarriage, Toxoplasmosis |
| spellingShingle | Zahra’a A. Ahmed Ekhlas M. Idan Naksheen M. Ardalan Role of IL-37 and Dectin-1 during Toxoplasmosis مجلة بغداد للعلوم C-type lectin receptor, Cytokine, Dectin-1, IL-37, Miscarriage, Toxoplasmosis |
| title | Role of IL-37 and Dectin-1 during Toxoplasmosis |
| title_full | Role of IL-37 and Dectin-1 during Toxoplasmosis |
| title_fullStr | Role of IL-37 and Dectin-1 during Toxoplasmosis |
| title_full_unstemmed | Role of IL-37 and Dectin-1 during Toxoplasmosis |
| title_short | Role of IL-37 and Dectin-1 during Toxoplasmosis |
| title_sort | role of il 37 and dectin 1 during toxoplasmosis |
| topic | C-type lectin receptor, Cytokine, Dectin-1, IL-37, Miscarriage, Toxoplasmosis |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7618 |
| work_keys_str_mv | AT zahraaaahmed roleofil37anddectin1duringtoxoplasmosis AT ekhlasmidan roleofil37anddectin1duringtoxoplasmosis AT naksheenmardalan roleofil37anddectin1duringtoxoplasmosis |