Evaluation of hypoglycemic potential of Cuminum cyminum and its role in modulation of cognitive function in rats with induced diabetes
Background: This study investigated the effects of Cuminum cyminum (C. cyminum) on cognitive behaviour and acetylcholinesterase (AChE) levels in diabetic rats, comparing its efficacy with Glibenclamide, Sulbutiamine, and Resveratrol. Methods: Wistar rats were randomized into 12 groups (n=10) half...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Creative Pharma Assent
2024-12-01
|
| Series: | Journal of Applied Pharmaceutical Research |
| Subjects: | |
| Online Access: | https://japtronline.com/index.php/joapr/article/view/549 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850100988077146112 |
|---|---|
| author | Abhishek Kumar Amit Shekhar Mitali Dua Indu Jangra Umesh Suranagi Ekta Arora |
| author_facet | Abhishek Kumar Amit Shekhar Mitali Dua Indu Jangra Umesh Suranagi Ekta Arora |
| author_sort | Abhishek Kumar |
| collection | DOAJ |
| description | Background: This study investigated the effects of Cuminum cyminum (C. cyminum) on cognitive behaviour and acetylcholinesterase (AChE) levels in diabetic rats, comparing its efficacy with Glibenclamide, Sulbutiamine, and Resveratrol.
Methods: Wistar rats were randomized into 12 groups (n=10) half diabetic and half non-diabetic controls and administered C. cyminum 500 mg/kg and 1000 mg/kg, Glibenclamide (5 mg/kg), Sulbutiamine (50 mg/kg), and Resveratrol (25 mg/kg). Controls included diabetic and non-diabetic rats without treatment. Blood glucose, insulin, oxidative stress markers, and AChE levels were measured, along with behavioural parameters of learning and memory using the elevated plus maze, passive avoidance, and Morris water maze.
Results: Both doses of C. cyminum significantly reduced blood glucose levels (Dose I decreased blood glucose levels from 278.5 ± 3.66 mg/dl to 136.8 ± 4.91 mg/dl while dose II decreased the blood glucose levels to 138.8 ± 3.83 mg/dl) and improved learning and memory, as evidenced by faster transfer latency (TL) and better retention in the elevated plus maze and Morris water maze. The higher dose was particularly effective in reducing brain AChE levels and improving cognitive performance in passive avoidance tests.
Conclusion: Both doses of C. cyminum decreased the AChE activity induced by diabetes, improving learning and memory. The antioxidant and anti-hyperglycaemic potential may partially contribute to delaying cognitive impairment. Thus, the study suggests that C. cyminum may be beneficial in mitigating behavioural and biochemical changes associated with diabetes mellitus, offering potential as a complementary therapy to existing diabetes treatments. Elaborate studies in the future are essential to explore its antidiabetic and neuroprotective potential. |
| format | Article |
| id | doaj-art-538d41f3f5f24a45a0b7117c76335b24 |
| institution | DOAJ |
| issn | 2348-0335 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Creative Pharma Assent |
| record_format | Article |
| series | Journal of Applied Pharmaceutical Research |
| spelling | doaj-art-538d41f3f5f24a45a0b7117c76335b242025-08-20T02:40:10ZengCreative Pharma AssentJournal of Applied Pharmaceutical Research2348-03352024-12-0112617018310.69857/joapr.v12i6.549550Evaluation of hypoglycemic potential of Cuminum cyminum and its role in modulation of cognitive function in rats with induced diabetesAbhishek Kumar0Amit Shekhar1Mitali Dua2Indu Jangra3Umesh SuranagiEkta Arora4Satyawadi Raja Harishchandra Hospital (SRHC), Narela, Delhi Government Health Services, Delhi- 110040, IndiaDepartment of Dermatology, Moti Lal Nehru Medical College, Prayagraj-211002, India Baba Saheb Ambedkar Hospital, Rohini, Delhi-110085, IndiaDepartment of Pharmacology, Government Institute of Medical Sciences (GIMS), Greater Noida-201310, India Department of Pharmacology, Lady Harding Medical College (LHMC), New Delhi-110001, IndiaBackground: This study investigated the effects of Cuminum cyminum (C. cyminum) on cognitive behaviour and acetylcholinesterase (AChE) levels in diabetic rats, comparing its efficacy with Glibenclamide, Sulbutiamine, and Resveratrol. Methods: Wistar rats were randomized into 12 groups (n=10) half diabetic and half non-diabetic controls and administered C. cyminum 500 mg/kg and 1000 mg/kg, Glibenclamide (5 mg/kg), Sulbutiamine (50 mg/kg), and Resveratrol (25 mg/kg). Controls included diabetic and non-diabetic rats without treatment. Blood glucose, insulin, oxidative stress markers, and AChE levels were measured, along with behavioural parameters of learning and memory using the elevated plus maze, passive avoidance, and Morris water maze. Results: Both doses of C. cyminum significantly reduced blood glucose levels (Dose I decreased blood glucose levels from 278.5 ± 3.66 mg/dl to 136.8 ± 4.91 mg/dl while dose II decreased the blood glucose levels to 138.8 ± 3.83 mg/dl) and improved learning and memory, as evidenced by faster transfer latency (TL) and better retention in the elevated plus maze and Morris water maze. The higher dose was particularly effective in reducing brain AChE levels and improving cognitive performance in passive avoidance tests. Conclusion: Both doses of C. cyminum decreased the AChE activity induced by diabetes, improving learning and memory. The antioxidant and anti-hyperglycaemic potential may partially contribute to delaying cognitive impairment. Thus, the study suggests that C. cyminum may be beneficial in mitigating behavioural and biochemical changes associated with diabetes mellitus, offering potential as a complementary therapy to existing diabetes treatments. Elaborate studies in the future are essential to explore its antidiabetic and neuroprotective potential.https://japtronline.com/index.php/joapr/article/view/549acetylcholinesterasecognitioncuminum cyminumdiabetes mellitussulbutiamineresveratrol |
| spellingShingle | Abhishek Kumar Amit Shekhar Mitali Dua Indu Jangra Umesh Suranagi Ekta Arora Evaluation of hypoglycemic potential of Cuminum cyminum and its role in modulation of cognitive function in rats with induced diabetes Journal of Applied Pharmaceutical Research acetylcholinesterase cognition cuminum cyminum diabetes mellitus sulbutiamine resveratrol |
| title | Evaluation of hypoglycemic potential of Cuminum cyminum and its role in modulation of cognitive function in rats with induced diabetes |
| title_full | Evaluation of hypoglycemic potential of Cuminum cyminum and its role in modulation of cognitive function in rats with induced diabetes |
| title_fullStr | Evaluation of hypoglycemic potential of Cuminum cyminum and its role in modulation of cognitive function in rats with induced diabetes |
| title_full_unstemmed | Evaluation of hypoglycemic potential of Cuminum cyminum and its role in modulation of cognitive function in rats with induced diabetes |
| title_short | Evaluation of hypoglycemic potential of Cuminum cyminum and its role in modulation of cognitive function in rats with induced diabetes |
| title_sort | evaluation of hypoglycemic potential of cuminum cyminum and its role in modulation of cognitive function in rats with induced diabetes |
| topic | acetylcholinesterase cognition cuminum cyminum diabetes mellitus sulbutiamine resveratrol |
| url | https://japtronline.com/index.php/joapr/article/view/549 |
| work_keys_str_mv | AT abhishekkumar evaluationofhypoglycemicpotentialofcuminumcyminumanditsroleinmodulationofcognitivefunctioninratswithinduceddiabetes AT amitshekhar evaluationofhypoglycemicpotentialofcuminumcyminumanditsroleinmodulationofcognitivefunctioninratswithinduceddiabetes AT mitalidua evaluationofhypoglycemicpotentialofcuminumcyminumanditsroleinmodulationofcognitivefunctioninratswithinduceddiabetes AT indujangra evaluationofhypoglycemicpotentialofcuminumcyminumanditsroleinmodulationofcognitivefunctioninratswithinduceddiabetes AT umeshsuranagi evaluationofhypoglycemicpotentialofcuminumcyminumanditsroleinmodulationofcognitivefunctioninratswithinduceddiabetes AT ektaarora evaluationofhypoglycemicpotentialofcuminumcyminumanditsroleinmodulationofcognitivefunctioninratswithinduceddiabetes |