Ectopic Pregnancy History as an Independent Factor Associated with Recurring Ectopic Pregnancy in Women with Bilateral Salpingectomies. A Matched-Pair Study of IVF Patients
Background: The incidence of ectopic pregnancy (EP) is purportedly elevated among individuals with a history of EP (referred to as the EP group) compared to those with no previous ectopic pregnancy (non-EP group). Nevertheless, the question of whether an EP history represents an autonomous risk fact...
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| Format: | Article |
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IMR Press
2024-03-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/51/3/10.31083/j.ceog5103076 |
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| author | Mingmei Lin Wanxue Xu Mingyu Liang Shuo Yang Rong Li |
| author_facet | Mingmei Lin Wanxue Xu Mingyu Liang Shuo Yang Rong Li |
| author_sort | Mingmei Lin |
| collection | DOAJ |
| description | Background: The incidence of ectopic pregnancy (EP) is purportedly elevated among individuals with a history of EP (referred to as the EP group) compared to those with no previous ectopic pregnancy (non-EP group). Nevertheless, the question of whether an EP history represents an autonomous risk factor for subsequent ectopic pregnancy of in vitro fertilization-embryo transfer (IVF-ET) patients remains a subject of debate. Methods: This study is a retrospective cohort study conducted at a single center. A total of sixty-seven patients with a prior ectopic pregnancy (EP) who underwent bilateral salpingectomy were included, and they were age-matched with a control group of 201 patients who did not have a history of EP but underwent bilateral salpingectomy during the period from January 2011 to April 2017. In all cases, laparoscopic salpingectomy was performed, followed by subsequent IVF-ET and frozen-thawed embryo transfer (FET) cycles. Results: The cumulative clinical pregnancy rates in the EP group and non-EP group were 65.7% and 73.6%, respectively, demonstrating no significant difference. Likewise, the cumulative live birth rates between the two groups were comparable (50.7% in the EP group vs. 63.6% in the non-EP group, p = 0.2). However, the incidence of ectopic pregnancy was significantly higher in the EP group compared to the non-EP group (15.9% vs. 3.4%, p = 0.003). Subsequent regression analyses revealed a significant association between a history of EP and an elevated risk of ectopic pregnancy. Conclusions: Women with a history of ectopic pregnancy even if they have had bilateral salpingectomies are at a significantly higher risk of subsequent ectopic pregnancies, indicating that a prior ectopic pregnancy is an independent risk factor for this condition, even if fallopian tubes have been removed. |
| format | Article |
| id | doaj-art-537f2540eb084942a94daaaf7e194fab |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-537f2540eb084942a94daaaf7e194fab2025-08-20T03:36:42ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-03-015137610.31083/j.ceog5103076S0390-6663(23)02293-5Ectopic Pregnancy History as an Independent Factor Associated with Recurring Ectopic Pregnancy in Women with Bilateral Salpingectomies. A Matched-Pair Study of IVF PatientsMingmei Lin0Wanxue Xu1Mingyu Liang2Shuo Yang3Rong Li4Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 100191 Beijing, ChinaDepartment of Gynecology and Obstetrics, Tianjin Medical University General Hospital, 300052 Tianjin, ChinaCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 100191 Beijing, ChinaCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 100191 Beijing, ChinaCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 100191 Beijing, ChinaBackground: The incidence of ectopic pregnancy (EP) is purportedly elevated among individuals with a history of EP (referred to as the EP group) compared to those with no previous ectopic pregnancy (non-EP group). Nevertheless, the question of whether an EP history represents an autonomous risk factor for subsequent ectopic pregnancy of in vitro fertilization-embryo transfer (IVF-ET) patients remains a subject of debate. Methods: This study is a retrospective cohort study conducted at a single center. A total of sixty-seven patients with a prior ectopic pregnancy (EP) who underwent bilateral salpingectomy were included, and they were age-matched with a control group of 201 patients who did not have a history of EP but underwent bilateral salpingectomy during the period from January 2011 to April 2017. In all cases, laparoscopic salpingectomy was performed, followed by subsequent IVF-ET and frozen-thawed embryo transfer (FET) cycles. Results: The cumulative clinical pregnancy rates in the EP group and non-EP group were 65.7% and 73.6%, respectively, demonstrating no significant difference. Likewise, the cumulative live birth rates between the two groups were comparable (50.7% in the EP group vs. 63.6% in the non-EP group, p = 0.2). However, the incidence of ectopic pregnancy was significantly higher in the EP group compared to the non-EP group (15.9% vs. 3.4%, p = 0.003). Subsequent regression analyses revealed a significant association between a history of EP and an elevated risk of ectopic pregnancy. Conclusions: Women with a history of ectopic pregnancy even if they have had bilateral salpingectomies are at a significantly higher risk of subsequent ectopic pregnancies, indicating that a prior ectopic pregnancy is an independent risk factor for this condition, even if fallopian tubes have been removed.https://www.imrpress.com/journal/CEOG/51/3/10.31083/j.ceog5103076bilateral salpingectomyectopic pregnancyassistive reproductive technology |
| spellingShingle | Mingmei Lin Wanxue Xu Mingyu Liang Shuo Yang Rong Li Ectopic Pregnancy History as an Independent Factor Associated with Recurring Ectopic Pregnancy in Women with Bilateral Salpingectomies. A Matched-Pair Study of IVF Patients Clinical and Experimental Obstetrics & Gynecology bilateral salpingectomy ectopic pregnancy assistive reproductive technology |
| title | Ectopic Pregnancy History as an Independent Factor Associated with Recurring Ectopic Pregnancy in Women with Bilateral Salpingectomies. A Matched-Pair Study of IVF Patients |
| title_full | Ectopic Pregnancy History as an Independent Factor Associated with Recurring Ectopic Pregnancy in Women with Bilateral Salpingectomies. A Matched-Pair Study of IVF Patients |
| title_fullStr | Ectopic Pregnancy History as an Independent Factor Associated with Recurring Ectopic Pregnancy in Women with Bilateral Salpingectomies. A Matched-Pair Study of IVF Patients |
| title_full_unstemmed | Ectopic Pregnancy History as an Independent Factor Associated with Recurring Ectopic Pregnancy in Women with Bilateral Salpingectomies. A Matched-Pair Study of IVF Patients |
| title_short | Ectopic Pregnancy History as an Independent Factor Associated with Recurring Ectopic Pregnancy in Women with Bilateral Salpingectomies. A Matched-Pair Study of IVF Patients |
| title_sort | ectopic pregnancy history as an independent factor associated with recurring ectopic pregnancy in women with bilateral salpingectomies a matched pair study of ivf patients |
| topic | bilateral salpingectomy ectopic pregnancy assistive reproductive technology |
| url | https://www.imrpress.com/journal/CEOG/51/3/10.31083/j.ceog5103076 |
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