Antibacterial effects of new endodontic materials based on calcium silicates
Background/Aim. The main task of endodontic treatment is to eliminate pathologically altered tissue, to disinfect root canal space and to obtain its three-dimensional hermetic obturation. The main purpose of this study was to evaluate antimicrobial activity of new endodontic nano-structured highly a...
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| Format: | Article |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2019-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501700130T.pdf |
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| author | Trišić Dijana Ćetenović Bojana Zdravković Nemanja Marković Tatjana Dojčinović Biljana Jokanović Vukoman Marković Dejan |
| author_facet | Trišić Dijana Ćetenović Bojana Zdravković Nemanja Marković Tatjana Dojčinović Biljana Jokanović Vukoman Marković Dejan |
| author_sort | Trišić Dijana |
| collection | DOAJ |
| description | Background/Aim. The main task of endodontic treatment is to eliminate pathologically altered tissue, to disinfect root canal space and to obtain its three-dimensional hermetic obturation. The main purpose of this study was to evaluate antimicrobial activity of new endodontic nano-structured highly active calcium silicates based materials albo-mineral plyoxide carbonate aggregate (ALBO-MPCA) and calcium silicates (CS) in comparison to mineral trioxide aggregate (MTA+) and UltraCal XS (CH). Methods. The antimicrobial activity of materials was tested against Staphylococcus aureus (ATCC 25923) and Enterococcus faecalis (ATCC 14506) strains, and following clinical isolates: Rothia dentocariosa, Enterococcus faecalis, Staphylococcus aureus, Streptococcus anginosus and Streptococcus vestibularis using a double layer agar diffusion test. The pH measurements were performed using the pH meter. Total amount of released ions was determined by inductively coupled plasma optical emission spectrometry (ICP-OES). Results. All tested materials showed the best antibacterial potential after 1 h of incubation. After 3h and 24h of the incubation period, the antibacterial potential of all tested materials were similar. The Agar diffusion test showed that ALBO-MPCA, CS and MTA+ had similar inhibition zones (p > 0.05), except in the activity against Staphylococcus aureus where ALBO-MPCA showed better antimicrobial properties than MTA+ in 3h and 24h of the incubation period (p < 0.05). Following 24h of the incubation, the inhibition zones were the strongest with CH against Staphylococcus aureus (16.67 ± 2.34 mm) followed by ALBO-MPCA (14.67 ± 1.21 mm) and the weakest with CS against Enterococcus faecalis (6.50 ± 1.76 mm). CH showed the highest pH, followed by ALBO-MPCA, CS and MTA+. Conclusion. The expressed antibacterial effects indicate that materials based on nano-structured highly active calcium silicates represent effective therapeutic agents for root canal obturation in one-visit apexification treatment, therefore they are recommend for further examination and clinical trials as they are proposed for MTA substitution. [Project of the Serbian
Ministry of Education, Science and Technological Development, Grant no.
172026 Grant no. TR31079] |
| format | Article |
| id | doaj-art-537ae23e84d24fc08ff0624c84ae15aa |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-537ae23e84d24fc08ff0624c84ae15aa2025-08-20T02:05:31ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202019-01-0176436537210.2298/VSP161231130T0042-84501700130TAntibacterial effects of new endodontic materials based on calcium silicatesTrišić Dijana0Ćetenović Bojana1Zdravković Nemanja2Marković Tatjana3Dojčinović Biljana4Jokanović Vukoman5Marković Dejan6Faculty of Dental Medicine, Belgrade Institute for Nuclear Sciences “Vinča“, BelgradeFaculty of Veterinary Medicine, BelgradeInstitute for Medicinal Plants Research, BelgradeInstitute of Chemistry, Technology and Metallurgy, BelgradeInstitute for Nuclear Sciences “Vinča“, BelgradeFaculty of Dental Medicine, Belgrade Background/Aim. The main task of endodontic treatment is to eliminate pathologically altered tissue, to disinfect root canal space and to obtain its three-dimensional hermetic obturation. The main purpose of this study was to evaluate antimicrobial activity of new endodontic nano-structured highly active calcium silicates based materials albo-mineral plyoxide carbonate aggregate (ALBO-MPCA) and calcium silicates (CS) in comparison to mineral trioxide aggregate (MTA+) and UltraCal XS (CH). Methods. The antimicrobial activity of materials was tested against Staphylococcus aureus (ATCC 25923) and Enterococcus faecalis (ATCC 14506) strains, and following clinical isolates: Rothia dentocariosa, Enterococcus faecalis, Staphylococcus aureus, Streptococcus anginosus and Streptococcus vestibularis using a double layer agar diffusion test. The pH measurements were performed using the pH meter. Total amount of released ions was determined by inductively coupled plasma optical emission spectrometry (ICP-OES). Results. All tested materials showed the best antibacterial potential after 1 h of incubation. After 3h and 24h of the incubation period, the antibacterial potential of all tested materials were similar. The Agar diffusion test showed that ALBO-MPCA, CS and MTA+ had similar inhibition zones (p > 0.05), except in the activity against Staphylococcus aureus where ALBO-MPCA showed better antimicrobial properties than MTA+ in 3h and 24h of the incubation period (p < 0.05). Following 24h of the incubation, the inhibition zones were the strongest with CH against Staphylococcus aureus (16.67 ± 2.34 mm) followed by ALBO-MPCA (14.67 ± 1.21 mm) and the weakest with CS against Enterococcus faecalis (6.50 ± 1.76 mm). CH showed the highest pH, followed by ALBO-MPCA, CS and MTA+. Conclusion. The expressed antibacterial effects indicate that materials based on nano-structured highly active calcium silicates represent effective therapeutic agents for root canal obturation in one-visit apexification treatment, therefore they are recommend for further examination and clinical trials as they are proposed for MTA substitution. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172026 Grant no. TR31079]http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501700130T.pdfdental pulp diseasesroot canal preparationcalcium silicatecalcium hydroxideanti-infective agents |
| spellingShingle | Trišić Dijana Ćetenović Bojana Zdravković Nemanja Marković Tatjana Dojčinović Biljana Jokanović Vukoman Marković Dejan Antibacterial effects of new endodontic materials based on calcium silicates Vojnosanitetski Pregled dental pulp diseases root canal preparation calcium silicate calcium hydroxide anti-infective agents |
| title | Antibacterial effects of new endodontic materials based on calcium silicates |
| title_full | Antibacterial effects of new endodontic materials based on calcium silicates |
| title_fullStr | Antibacterial effects of new endodontic materials based on calcium silicates |
| title_full_unstemmed | Antibacterial effects of new endodontic materials based on calcium silicates |
| title_short | Antibacterial effects of new endodontic materials based on calcium silicates |
| title_sort | antibacterial effects of new endodontic materials based on calcium silicates |
| topic | dental pulp diseases root canal preparation calcium silicate calcium hydroxide anti-infective agents |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501700130T.pdf |
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