Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemia
JAK2 V617F (JAK2) mutation is associated with clonal hemopoiesis in myeloproliferative neoplasms as well as with faster progression of cardiovascular diseases. Little is known about the relationship between allele burden and the degree of atherosclerotic alteration of coronary vasculature. We previo...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-10-01
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| Series: | Radiology and Oncology |
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| Online Access: | https://doi.org/10.2478/raon-2024-0036 |
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| author | Drofenik Ajda Blinc Ales Bozic Mijovski Mojca Pajic Tadej Vrtovec Matjaz Sever Matjaz |
| author_facet | Drofenik Ajda Blinc Ales Bozic Mijovski Mojca Pajic Tadej Vrtovec Matjaz Sever Matjaz |
| author_sort | Drofenik Ajda |
| collection | DOAJ |
| description | JAK2 V617F (JAK2) mutation is associated with clonal hemopoiesis in myeloproliferative neoplasms as well as with faster progression of cardiovascular diseases. Little is known about the relationship between allele burden and the degree of atherosclerotic alteration of coronary vasculature. We previously reported that carotid artery stiffness progressed faster in patients with JAK2 positive essential thromocythemia (ET) patients. After a four-year follow-up we investigated whether mutation burden of a JAK2 allele correlates with a higher coronary calcium score. |
| format | Article |
| id | doaj-art-537a7cc588084dd9ad54dadc72bdeca8 |
| institution | Kabale University |
| issn | 1581-3207 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj-art-537a7cc588084dd9ad54dadc72bdeca82025-01-07T07:56:43ZengSciendoRadiology and Oncology1581-32072024-10-0158456557210.2478/raon-2024-0036Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemiaDrofenik Ajda0Blinc Ales1Bozic Mijovski Mojca2Pajic Tadej3Vrtovec Matjaz4Sever Matjaz5Department of Cardiology, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of Vascular Diseases, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of Vascular Diseases, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaClinical Institute for Genomic Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of Vascular Diseases, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaJAK2 V617F (JAK2) mutation is associated with clonal hemopoiesis in myeloproliferative neoplasms as well as with faster progression of cardiovascular diseases. Little is known about the relationship between allele burden and the degree of atherosclerotic alteration of coronary vasculature. We previously reported that carotid artery stiffness progressed faster in patients with JAK2 positive essential thromocythemia (ET) patients. After a four-year follow-up we investigated whether mutation burden of a JAK2 allele correlates with a higher coronary calcium score.https://doi.org/10.2478/raon-2024-0036essential thrombocythemiajak2 v617f mutationjak2 v617f allele burdencoronary calcium score |
| spellingShingle | Drofenik Ajda Blinc Ales Bozic Mijovski Mojca Pajic Tadej Vrtovec Matjaz Sever Matjaz Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemia Radiology and Oncology essential thrombocythemia jak2 v617f mutation jak2 v617f allele burden coronary calcium score |
| title | Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemia |
| title_full | Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemia |
| title_fullStr | Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemia |
| title_full_unstemmed | Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemia |
| title_short | Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemia |
| title_sort | relation of jak2 v617f allele burden and coronary calcium score in patients with essential thrombocythemia |
| topic | essential thrombocythemia jak2 v617f mutation jak2 v617f allele burden coronary calcium score |
| url | https://doi.org/10.2478/raon-2024-0036 |
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