In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis
This study evaluated the biodistribution of gum arabic-functionalized gold nanoparticles (GA-AuNPs) in Balb/C Nude mice following intravenous administration. Two activity regimens (200 µCi and 600 µCi) were analyzed at two different time points (3 and 24 hours post-injection). The results showed pre...
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| Format: | Article |
| Language: | English |
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2025-06-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2602 |
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| author | Angélica Barbezan Wilmmer Alexander Rosero Luis Fernando Almeida Maria Eduarda Rigo Fabio Fernando Silva Maria Elisa Rostelato |
| author_facet | Angélica Barbezan Wilmmer Alexander Rosero Luis Fernando Almeida Maria Eduarda Rigo Fabio Fernando Silva Maria Elisa Rostelato |
| author_sort | Angélica Barbezan |
| collection | DOAJ |
| description | This study evaluated the biodistribution of gum arabic-functionalized gold nanoparticles (GA-AuNPs) in Balb/C Nude mice following intravenous administration. Two activity regimens (200 µCi and 600 µCi) were analyzed at two different time points (3 and 24 hours post-injection). The results showed predominant accumulation of GA-AuNPs in the liver, spleen, and gallbladder, suggesting hepatobiliary excretion as the primary clearance route. A reduction in liver uptake after 24 hours indicates potential nanoparticle metabolism or elimination. Although this study focused on intravenous delivery, previous work from our group using BSA-coated AuNPs administered intratumorally demonstrated higher tumor retention and reduced systemic accumulation, reinforcing the importance of administration route and surface coating in defining nanoparticle biodistribution. These findings contribute to the understanding of how delivery strategy influences nanoparticle bioavailability and support the development of safer and more targeted therapeutic platforms.
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| format | Article |
| id | doaj-art-5379bf6738c54b4dadef09577da5ac6a |
| institution | DOAJ |
| issn | 2319-0612 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-5379bf6738c54b4dadef09577da5ac6a2025-08-20T03:12:31ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122025-06-01124A (Suppl.)10.15392/2319-0612.2024.26022227In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysisAngélica Barbezan0https://orcid.org/0000-0001-7615-9091Wilmmer Alexander Rosero1Luis Fernando Almeida2Maria Eduarda Rigo3Fabio Fernando Silva4Maria Elisa Rostelato5Instituto de Pesquisas Energéticas e Nucleares - IPENInstituto de Pesquisas Energéticas e Nucleares - IPENInstituto de Pesquisas Energéticas e Nucleares - IPENInstituto de Pesquisas Energéticas e Nucleares - IPENInstituto de Pesquisas Energéticas e Nucleares - IPENInstituto de Pesquisas Energéticas e Nucleares - IPENThis study evaluated the biodistribution of gum arabic-functionalized gold nanoparticles (GA-AuNPs) in Balb/C Nude mice following intravenous administration. Two activity regimens (200 µCi and 600 µCi) were analyzed at two different time points (3 and 24 hours post-injection). The results showed predominant accumulation of GA-AuNPs in the liver, spleen, and gallbladder, suggesting hepatobiliary excretion as the primary clearance route. A reduction in liver uptake after 24 hours indicates potential nanoparticle metabolism or elimination. Although this study focused on intravenous delivery, previous work from our group using BSA-coated AuNPs administered intratumorally demonstrated higher tumor retention and reduced systemic accumulation, reinforcing the importance of administration route and surface coating in defining nanoparticle biodistribution. These findings contribute to the understanding of how delivery strategy influences nanoparticle bioavailability and support the development of safer and more targeted therapeutic platforms. https://bjrs.org.br/revista/index.php/REVISTA/article/view/2602Gold Nanoparticles (AuNPs)NanobrachytherapyGum Arabic (GA)Biodistribution |
| spellingShingle | Angélica Barbezan Wilmmer Alexander Rosero Luis Fernando Almeida Maria Eduarda Rigo Fabio Fernando Silva Maria Elisa Rostelato In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis Brazilian Journal of Radiation Sciences Gold Nanoparticles (AuNPs) Nanobrachytherapy Gum Arabic (GA) Biodistribution |
| title | In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis |
| title_full | In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis |
| title_fullStr | In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis |
| title_full_unstemmed | In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis |
| title_short | In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis |
| title_sort | in vivo distribution dynamics of gold nanoparticles a quantitative analysis |
| topic | Gold Nanoparticles (AuNPs) Nanobrachytherapy Gum Arabic (GA) Biodistribution |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2602 |
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