Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overview
Pharmaceutical excipients such as P-glycoprotein inhibitors can also increase the solubility and affinity of drugs to the intestinal membrane, enhance paracellular pathways and endocyte uptake, and activate lymph transport pathways, thereby increasing the bioavailability of oral drugs. This review a...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2025-02-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/140734/download/pdf/ |
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| author | Fitrianti Darusman Taofik Rusdiana Iyan Sopyan Hanifa Rahma Millati Hanifa |
| author_facet | Fitrianti Darusman Taofik Rusdiana Iyan Sopyan Hanifa Rahma Millati Hanifa |
| author_sort | Fitrianti Darusman |
| collection | DOAJ |
| description | Pharmaceutical excipients such as P-glycoprotein inhibitors can also increase the solubility and affinity of drugs to the intestinal membrane, enhance paracellular pathways and endocyte uptake, and activate lymph transport pathways, thereby increasing the bioavailability of oral drugs. This review aims to review and assess the performance of pharmaceutical excipients as P-glycoprotein permeability inhibitors in improving oral drug bioavailability in drug formulations by evaluating meta data from P-glycoprotein efflux in permeability and pharmacokinetics studies. The review results are pharmaceutical excipients that have proven effective as P-glycoprotein inhibitors from the surfactant and polymer groups, namely TPGS and Poloxamer 188, respectively. All nanosystems incorporating pharmaceutical excipients as P-gp inhibitors show potential in enhancing the permeability and bioavailability of oral drugs when compared to conventional formulations. The effectiveness of these systems has been evaluated through in vitro (Caco-2 cells), ex vivo (everted gut sac), in situ (SPIP), and in vivo (AUC) methods. |
| format | Article |
| id | doaj-art-536c609119f84bdba5eb2f4c20357168 |
| institution | Kabale University |
| issn | 2603-557X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj-art-536c609119f84bdba5eb2f4c203571682025-02-09T08:31:17ZengPensoft PublishersPharmacia2603-557X2025-02-017211610.3897/pharmacia.72.e140734140734Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overviewFitrianti Darusman0Taofik Rusdiana1Iyan Sopyan2Hanifa Rahma3Millati Hanifa4Bandung Islamic UniversityPadjadjaran UniversityPadjadjaran UniversityBandung Islamic UniversityBandung Islamic UniversityPharmaceutical excipients such as P-glycoprotein inhibitors can also increase the solubility and affinity of drugs to the intestinal membrane, enhance paracellular pathways and endocyte uptake, and activate lymph transport pathways, thereby increasing the bioavailability of oral drugs. This review aims to review and assess the performance of pharmaceutical excipients as P-glycoprotein permeability inhibitors in improving oral drug bioavailability in drug formulations by evaluating meta data from P-glycoprotein efflux in permeability and pharmacokinetics studies. The review results are pharmaceutical excipients that have proven effective as P-glycoprotein inhibitors from the surfactant and polymer groups, namely TPGS and Poloxamer 188, respectively. All nanosystems incorporating pharmaceutical excipients as P-gp inhibitors show potential in enhancing the permeability and bioavailability of oral drugs when compared to conventional formulations. The effectiveness of these systems has been evaluated through in vitro (Caco-2 cells), ex vivo (everted gut sac), in situ (SPIP), and in vivo (AUC) methods.https://pharmacia.pensoft.net/article/140734/download/pdf/ |
| spellingShingle | Fitrianti Darusman Taofik Rusdiana Iyan Sopyan Hanifa Rahma Millati Hanifa Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overview Pharmacia |
| title | Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overview |
| title_full | Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overview |
| title_fullStr | Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overview |
| title_full_unstemmed | Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overview |
| title_short | Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overview |
| title_sort | recent progress in pharmaceutical excipients as p glycoprotein inhibitors for potential improvement of oral drug bioavailability a comprehensive overview |
| url | https://pharmacia.pensoft.net/article/140734/download/pdf/ |
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