Drug-coated balloon in patients with in-stent restenosis: A prospective observational study
Aim: The aim of this study was to compare the safety and efficacy of paclitaxel-coated balloons (PCB) and sirolimus-coated balloons (SCB) in patients with in-stent restenosis (ISR). Methods: This prospective, observational, single-centre pilot study enrolled 85 patients diagnosed with drug-eluting s...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Indian Heart Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483225000495 |
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| author | Shuvanan Ray Siddhartha Bandyopadhyay Prithwiraj Bhattacharjee Priyam Mukherjee Suman Karmakar Pallab Bose Basabendra Choudhury Deepankar Paul Avik Karak |
| author_facet | Shuvanan Ray Siddhartha Bandyopadhyay Prithwiraj Bhattacharjee Priyam Mukherjee Suman Karmakar Pallab Bose Basabendra Choudhury Deepankar Paul Avik Karak |
| author_sort | Shuvanan Ray |
| collection | DOAJ |
| description | Aim: The aim of this study was to compare the safety and efficacy of paclitaxel-coated balloons (PCB) and sirolimus-coated balloons (SCB) in patients with in-stent restenosis (ISR). Methods: This prospective, observational, single-centre pilot study enrolled 85 patients diagnosed with drug-eluting stent ISR. For all the eligible patients, various clinical baseline characteristics were collected, and angiography was performed to evaluate the lesion characteristics. After assessment, patients were treated with either PCB or SCB based on our center's time-based approach. Intravascular ultrasound (IVUS) imagining was used to assess the pre- and post-procedural minimal stent area (MSA). All the patients were followed up and major adverse cardiovascular events were documented for patients in both the groups. Results: Of total 85 patients with ISR, 32 underwent treatment with PCB and 53 with SCB. A significant difference was noted in the post procedural MSA in both the groups (p = 0.005) and the values were 7.01 ± 1.11 mm2 and 8.01 ± 1.70 mm2 for PCB and SCB group, respectively. At median follow-up of 3.8 years, no cardiac death was noted in PCB group and one death was reported in SCB group (p = 0.459). In PCB group, target lesion revascularization (TLR) was noted in one (12.5 %) patient, while in SCB group TLR was noted in four (16.5 %) patients (p = 0.920). Conclusion: Both PCB and SCB are found to be effective and safe in treating in patients with drug-eluting stents-ISR. Also, the use of DCB with imaging techniques like IVUS enhances treatment outcomes and optimizes patient care in ISR treatment. |
| format | Article |
| id | doaj-art-536a3b23a58c4a98bb4b09285ffb70d4 |
| institution | Kabale University |
| issn | 0019-4832 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj-art-536a3b23a58c4a98bb4b09285ffb70d42025-08-20T03:47:31ZengElsevierIndian Heart Journal0019-48322025-03-0177210510910.1016/j.ihj.2025.03.003Drug-coated balloon in patients with in-stent restenosis: A prospective observational studyShuvanan Ray0Siddhartha Bandyopadhyay1Prithwiraj Bhattacharjee2Priyam Mukherjee3Suman Karmakar4Pallab Bose5Basabendra Choudhury6Deepankar Paul7Avik Karak8Fortis Hospital, Anandapur, West Bengal, 700107, India; Corresponding author.Fortis Hospital, Anandapur, West Bengal, 700107, IndiaFortis Hospital, Anandapur, West Bengal, 700107, IndiaFortis Hospital, Anandapur, West Bengal, 700107, IndiaFortis Hospital, Anandapur, West Bengal, 700107, IndiaFortis Hospital, Anandapur, West Bengal, 700107, IndiaFortis Hospital, Anandapur, West Bengal, 700107, IndiaIntensive Care, CCU, ECSMG, Fortis Hospital, Anandapur, West Bengal, 700107, IndiaFortis Hospital, Anandapur, West Bengal, 700107, IndiaAim: The aim of this study was to compare the safety and efficacy of paclitaxel-coated balloons (PCB) and sirolimus-coated balloons (SCB) in patients with in-stent restenosis (ISR). Methods: This prospective, observational, single-centre pilot study enrolled 85 patients diagnosed with drug-eluting stent ISR. For all the eligible patients, various clinical baseline characteristics were collected, and angiography was performed to evaluate the lesion characteristics. After assessment, patients were treated with either PCB or SCB based on our center's time-based approach. Intravascular ultrasound (IVUS) imagining was used to assess the pre- and post-procedural minimal stent area (MSA). All the patients were followed up and major adverse cardiovascular events were documented for patients in both the groups. Results: Of total 85 patients with ISR, 32 underwent treatment with PCB and 53 with SCB. A significant difference was noted in the post procedural MSA in both the groups (p = 0.005) and the values were 7.01 ± 1.11 mm2 and 8.01 ± 1.70 mm2 for PCB and SCB group, respectively. At median follow-up of 3.8 years, no cardiac death was noted in PCB group and one death was reported in SCB group (p = 0.459). In PCB group, target lesion revascularization (TLR) was noted in one (12.5 %) patient, while in SCB group TLR was noted in four (16.5 %) patients (p = 0.920). Conclusion: Both PCB and SCB are found to be effective and safe in treating in patients with drug-eluting stents-ISR. Also, the use of DCB with imaging techniques like IVUS enhances treatment outcomes and optimizes patient care in ISR treatment.http://www.sciencedirect.com/science/article/pii/S0019483225000495Coronary balloon angioplastyCoronary restenosisDeathDrug-eluting stentsPaclitaxelSirolimus |
| spellingShingle | Shuvanan Ray Siddhartha Bandyopadhyay Prithwiraj Bhattacharjee Priyam Mukherjee Suman Karmakar Pallab Bose Basabendra Choudhury Deepankar Paul Avik Karak Drug-coated balloon in patients with in-stent restenosis: A prospective observational study Indian Heart Journal Coronary balloon angioplasty Coronary restenosis Death Drug-eluting stents Paclitaxel Sirolimus |
| title | Drug-coated balloon in patients with in-stent restenosis: A prospective observational study |
| title_full | Drug-coated balloon in patients with in-stent restenosis: A prospective observational study |
| title_fullStr | Drug-coated balloon in patients with in-stent restenosis: A prospective observational study |
| title_full_unstemmed | Drug-coated balloon in patients with in-stent restenosis: A prospective observational study |
| title_short | Drug-coated balloon in patients with in-stent restenosis: A prospective observational study |
| title_sort | drug coated balloon in patients with in stent restenosis a prospective observational study |
| topic | Coronary balloon angioplasty Coronary restenosis Death Drug-eluting stents Paclitaxel Sirolimus |
| url | http://www.sciencedirect.com/science/article/pii/S0019483225000495 |
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