NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition
NMDA ionotropic glutamate receptors (NMDARs) are crucial in activity-dependent synaptic changes and in learning and memory. NMDARs are composed of two GluN1 essential subunits and two regulatory subunits which define their pharmacological and physiological profile. In CNS structures involved in cogn...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/5093048 |
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| author | María Verónica Baez Magalí Cecilia Cercato Diana Alicia Jerusalinsky |
| author_facet | María Verónica Baez Magalí Cecilia Cercato Diana Alicia Jerusalinsky |
| author_sort | María Verónica Baez |
| collection | DOAJ |
| description | NMDA ionotropic glutamate receptors (NMDARs) are crucial in activity-dependent synaptic changes and in learning and memory. NMDARs are composed of two GluN1 essential subunits and two regulatory subunits which define their pharmacological and physiological profile. In CNS structures involved in cognitive functions as the hippocampus and prefrontal cortex, GluN2A and GluN2B are major regulatory subunits; their expression is dynamic and tightly regulated, but little is known about specific changes after plasticity induction or memory acquisition. Data strongly suggest that following appropriate stimulation, there is a rapid increase in surface GluN2A-NMDAR at the postsynapses, attributed to lateral receptor mobilization from adjacent locations. Whenever synaptic plasticity is induced or memory is consolidated, more GluN2A-NMDARs are assembled likely using GluN2A from a local translation and GluN1 from local ER. Later on, NMDARs are mobilized from other pools, and there are de novo syntheses at the neuron soma. Changes in GluN1 or NMDAR levels induced by synaptic plasticity and by spatial memory formation seem to occur in different waves of NMDAR transport/expression/degradation, with a net increase at the postsynaptic side and a rise in expression at both the spine and neuronal soma. This review aims to put together that information and the proposed hypotheses. |
| format | Article |
| id | doaj-art-5367f45f3cf04c9a85745a13930ce6f1 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-5367f45f3cf04c9a85745a13930ce6f12025-02-03T01:12:59ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/50930485093048NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory AcquisitionMaría Verónica Baez0Magalí Cecilia Cercato1Diana Alicia Jerusalinsky2Instituto de Biología Celular y Neurociencia “Prof. E. De Robertis”, UBA-CONICET, School of Medicine, University of Buenos Aires, 2155 Paraguay St., 1121 CABA, ArgentinaInstituto de Biología Celular y Neurociencia “Prof. E. De Robertis”, UBA-CONICET, School of Medicine, University of Buenos Aires, 2155 Paraguay St., 1121 CABA, ArgentinaInstituto de Biología Celular y Neurociencia “Prof. E. De Robertis”, UBA-CONICET, School of Medicine, University of Buenos Aires, 2155 Paraguay St., 1121 CABA, ArgentinaNMDA ionotropic glutamate receptors (NMDARs) are crucial in activity-dependent synaptic changes and in learning and memory. NMDARs are composed of two GluN1 essential subunits and two regulatory subunits which define their pharmacological and physiological profile. In CNS structures involved in cognitive functions as the hippocampus and prefrontal cortex, GluN2A and GluN2B are major regulatory subunits; their expression is dynamic and tightly regulated, but little is known about specific changes after plasticity induction or memory acquisition. Data strongly suggest that following appropriate stimulation, there is a rapid increase in surface GluN2A-NMDAR at the postsynapses, attributed to lateral receptor mobilization from adjacent locations. Whenever synaptic plasticity is induced or memory is consolidated, more GluN2A-NMDARs are assembled likely using GluN2A from a local translation and GluN1 from local ER. Later on, NMDARs are mobilized from other pools, and there are de novo syntheses at the neuron soma. Changes in GluN1 or NMDAR levels induced by synaptic plasticity and by spatial memory formation seem to occur in different waves of NMDAR transport/expression/degradation, with a net increase at the postsynaptic side and a rise in expression at both the spine and neuronal soma. This review aims to put together that information and the proposed hypotheses.http://dx.doi.org/10.1155/2018/5093048 |
| spellingShingle | María Verónica Baez Magalí Cecilia Cercato Diana Alicia Jerusalinsky NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition Neural Plasticity |
| title | NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition |
| title_full | NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition |
| title_fullStr | NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition |
| title_full_unstemmed | NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition |
| title_short | NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition |
| title_sort | nmda receptor subunits change after synaptic plasticity induction and learning and memory acquisition |
| url | http://dx.doi.org/10.1155/2018/5093048 |
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