Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case Series
Background. Esophageal intramural pseudodiverticulosis (EIPD) is an idiopathic benign chronic disease characterized by flask-like outpouchings of the esophageal wall. It is unknown whether there is a genuine association between EIPD and eosinophilic esophagitis (EoE). Aims. To investigate a possible...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2016/1761874 |
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| author | Michael A. Scaffidi Ankit Garg Brandon Ro Christopher Wang Tony T. C. Yang Ian S. Plener Andrea Grin Errol Colak Samir C. Grover |
| author_facet | Michael A. Scaffidi Ankit Garg Brandon Ro Christopher Wang Tony T. C. Yang Ian S. Plener Andrea Grin Errol Colak Samir C. Grover |
| author_sort | Michael A. Scaffidi |
| collection | DOAJ |
| description | Background. Esophageal intramural pseudodiverticulosis (EIPD) is an idiopathic benign chronic disease characterized by flask-like outpouchings of the esophageal wall. It is unknown whether there is a genuine association between EIPD and eosinophilic esophagitis (EoE). Aims. To investigate a possible relationship between EIPD and EoE. Methods. Patients with radiographic or endoscopic evidence of pseudodiverticulosis were identified from the database at a single academic center. Cases were analyzed in three areas: clinical information, endoscopic findings, and course. Results. Sixteen cases of esophageal pseudodiverticulosis were identified. Five patients had histologic evidence of eosinophilic esophagitis. Patients with EoE had pseudodiverticula in the mid-to-distal esophagus while those with EIPD had pseudodiverticula predominantly in the proximal esophagus (p<0.001). EoE with pseudodiverticulosis occurred in younger patients (p<0.019). Food bolus obstructions were more common in patients with EoE and pseudodiverticulosis than in EIPD (p<0.034). Conclusions. This is the first case series supporting a potential association between EoE and pseudodiverticulosis. We also identify characteristic features of pseudodiverticulosis that may raise clinical suspicion of underlying eosinophilic esophagitis. |
| format | Article |
| id | doaj-art-5360742663744b0f9cd88f6b420c120a |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-5360742663744b0f9cd88f6b420c120a2025-02-03T00:59:51ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972016-01-01201610.1155/2016/17618741761874Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case SeriesMichael A. Scaffidi0Ankit Garg1Brandon Ro2Christopher Wang3Tony T. C. Yang4Ian S. Plener5Andrea Grin6Errol Colak7Samir C. Grover8Division of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaLaboratory Medicine and Pathobiology, St. Michael’s Hospital, Toronto, ON, CanadaDepartment of Medical Imaging, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaBackground. Esophageal intramural pseudodiverticulosis (EIPD) is an idiopathic benign chronic disease characterized by flask-like outpouchings of the esophageal wall. It is unknown whether there is a genuine association between EIPD and eosinophilic esophagitis (EoE). Aims. To investigate a possible relationship between EIPD and EoE. Methods. Patients with radiographic or endoscopic evidence of pseudodiverticulosis were identified from the database at a single academic center. Cases were analyzed in three areas: clinical information, endoscopic findings, and course. Results. Sixteen cases of esophageal pseudodiverticulosis were identified. Five patients had histologic evidence of eosinophilic esophagitis. Patients with EoE had pseudodiverticula in the mid-to-distal esophagus while those with EIPD had pseudodiverticula predominantly in the proximal esophagus (p<0.001). EoE with pseudodiverticulosis occurred in younger patients (p<0.019). Food bolus obstructions were more common in patients with EoE and pseudodiverticulosis than in EIPD (p<0.034). Conclusions. This is the first case series supporting a potential association between EoE and pseudodiverticulosis. We also identify characteristic features of pseudodiverticulosis that may raise clinical suspicion of underlying eosinophilic esophagitis.http://dx.doi.org/10.1155/2016/1761874 |
| spellingShingle | Michael A. Scaffidi Ankit Garg Brandon Ro Christopher Wang Tony T. C. Yang Ian S. Plener Andrea Grin Errol Colak Samir C. Grover Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case Series Canadian Journal of Gastroenterology and Hepatology |
| title | Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case Series |
| title_full | Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case Series |
| title_fullStr | Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case Series |
| title_full_unstemmed | Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case Series |
| title_short | Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case Series |
| title_sort | esophageal intramural pseudodiverticulosis and concomitant eosinophilic esophagitis a case series |
| url | http://dx.doi.org/10.1155/2016/1761874 |
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