Circulating cell-free DNA methylation as biomarker for lung cancer detection: a systematic review and meta-analysis of diagnostic studies

Abstract Lung cancer (LC) is the most incident malignancy and a leading cause of cancer-related fatalities. The lack of dissemination of effective screening tools hinders early detection, resulting in late-stage diagnosis, mostly associated with high mortality. Gene-specific methylation alterations...

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Bibliographic Details
Main Authors: Diana Inês Machado, Tiago Brito-Rocha, Sofia Salta, Teresa Monjardino, Rui Henrique, Carmen Jerónimo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Systematic Reviews
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Online Access:https://doi.org/10.1186/s13643-025-02860-w
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