Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice

Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice

Abstract The intestinal mucosa harbors diverse lymphocyte populations, including double negative CD4–CD8αβ–TCRαβ+ T (DNT) cells, in the intraepithelial compartment and the lamina propria. Here we report that DNT cells in mouse small intestines are motile and reach across the epithelial barrier to ca...

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Main Authors: Yasuhiro Nemoto, Ryo Morikawa, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Kento Takenaka, Kazuo Ohtsuka, Xigui Chen, Hitoshi Okazawa, Ryuichi Okamoto, Mamoru Watanabe, Ulrich H. von Andrian
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62089-y
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https://doi.org/10.1038/s41467-025-62089-y

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