Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance
Abstract Pancreatic cancer (PaC) is one of the most aggressive malignancies. The dismal survival rate of PaC patients is mainly due to the late diagnosis and their resistance to conventional chemotherapies. Emerging evidence suggests that miRNA can serve as a potential new diagnostic and therapeutic...
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| Format: | Article |
| Language: | English |
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ELS Publishing (ELSP)
2019-04-01
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| Series: | ExRNA |
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| Online Access: | http://link.springer.com/article/10.1186/s41544-019-0014-0 |
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| author | Xiaohong Jiang Dongxia Hou Zhe Wei Shasha Zheng Yujing Zhang Jing Li |
| author_facet | Xiaohong Jiang Dongxia Hou Zhe Wei Shasha Zheng Yujing Zhang Jing Li |
| author_sort | Xiaohong Jiang |
| collection | DOAJ |
| description | Abstract Pancreatic cancer (PaC) is one of the most aggressive malignancies. The dismal survival rate of PaC patients is mainly due to the late diagnosis and their resistance to conventional chemotherapies. Emerging evidence suggests that miRNA can serve as a potential new diagnostic and therapeutic weapon to fight against PaC. Circulating miRNAs represent the most promising noninvasive tools for diagnosis owing to their high stability in blood. Combinations of circulating miRNAs with other serum indicators such as carbohydrate antigen 19–9 (CA19–9) were demonstrated to be valuable biomarkers for early PaC diagnosis. As miRNAs can regulate epithelial-mesenchymal transition (EMT) and the progression of cancer stem cells (CSCs), two critical factors in PaC drug resistance, selectively manipulating miRNAs may improve the sensitivity of certain PaC chemotherapeutic agents, such as gemcitabine. Therefore, the investigations of miRNAs in PaC may provide potential novel approaches for both tumor diagnosis and treatment. |
| format | Article |
| id | doaj-art-53541ced298843c082c570908b2ea2a9 |
| institution | DOAJ |
| issn | 2398-0060 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | ELS Publishing (ELSP) |
| record_format | Article |
| series | ExRNA |
| spelling | doaj-art-53541ced298843c082c570908b2ea2a92025-08-20T03:14:45ZengELS Publishing (ELSP)ExRNA2398-00602019-04-011111010.1186/s41544-019-0014-0Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistanceXiaohong Jiang0Dongxia Hou1Zhe Wei2Shasha Zheng3Yujing Zhang4Jing Li5State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing UniversityAbstract Pancreatic cancer (PaC) is one of the most aggressive malignancies. The dismal survival rate of PaC patients is mainly due to the late diagnosis and their resistance to conventional chemotherapies. Emerging evidence suggests that miRNA can serve as a potential new diagnostic and therapeutic weapon to fight against PaC. Circulating miRNAs represent the most promising noninvasive tools for diagnosis owing to their high stability in blood. Combinations of circulating miRNAs with other serum indicators such as carbohydrate antigen 19–9 (CA19–9) were demonstrated to be valuable biomarkers for early PaC diagnosis. As miRNAs can regulate epithelial-mesenchymal transition (EMT) and the progression of cancer stem cells (CSCs), two critical factors in PaC drug resistance, selectively manipulating miRNAs may improve the sensitivity of certain PaC chemotherapeutic agents, such as gemcitabine. Therefore, the investigations of miRNAs in PaC may provide potential novel approaches for both tumor diagnosis and treatment.http://link.springer.com/article/10.1186/s41544-019-0014-0Pancreatic cancerCirculating microRNAsBiomarkersEpithelial-mesenchymal transitionChemoresistance |
| spellingShingle | Xiaohong Jiang Dongxia Hou Zhe Wei Shasha Zheng Yujing Zhang Jing Li Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance ExRNA Pancreatic cancer Circulating microRNAs Biomarkers Epithelial-mesenchymal transition Chemoresistance |
| title | Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance |
| title_full | Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance |
| title_fullStr | Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance |
| title_full_unstemmed | Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance |
| title_short | Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance |
| title_sort | extracellular and intracellular micrornas in pancreatic cancer from early diagnosis to reducing chemoresistance |
| topic | Pancreatic cancer Circulating microRNAs Biomarkers Epithelial-mesenchymal transition Chemoresistance |
| url | http://link.springer.com/article/10.1186/s41544-019-0014-0 |
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