Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood Cells
Red blood cells (RBCs) are highly specialized cells with a limited metabolic repertoire. However, it has been demonstrated that metabolic processes are affected by the production of reactive oxygen species (ROS), and critical enzymes allied to metabolic pathways can be impaired by redox reactions. T...
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| Format: | Article |
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MDPI AG
2024-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/23/2026 |
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| author | Sara Spinelli Angela Marino Rossana Morabito Alessia Remigante |
| author_facet | Sara Spinelli Angela Marino Rossana Morabito Alessia Remigante |
| author_sort | Sara Spinelli |
| collection | DOAJ |
| description | Red blood cells (RBCs) are highly specialized cells with a limited metabolic repertoire. However, it has been demonstrated that metabolic processes are affected by the production of reactive oxygen species (ROS), and critical enzymes allied to metabolic pathways can be impaired by redox reactions. Thus, oxidative stress-induced alternations in the metabolic pathways can contribute to cell dysfunction of human RBCs. Herein, we aim to provide an overview on the metabolic pathways of human RBCs, focusing on their pathophysiological relevance and their regulation in oxidative stress-related conditions. |
| format | Article |
| id | doaj-art-53529fd985694039acacce02c8dc2cfa |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-53529fd985694039acacce02c8dc2cfa2025-08-20T02:38:47ZengMDPI AGCells2073-44092024-12-011323202610.3390/cells13232026Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood CellsSara Spinelli0Angela Marino1Rossana Morabito2Alessia Remigante3Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyRed blood cells (RBCs) are highly specialized cells with a limited metabolic repertoire. However, it has been demonstrated that metabolic processes are affected by the production of reactive oxygen species (ROS), and critical enzymes allied to metabolic pathways can be impaired by redox reactions. Thus, oxidative stress-induced alternations in the metabolic pathways can contribute to cell dysfunction of human RBCs. Herein, we aim to provide an overview on the metabolic pathways of human RBCs, focusing on their pathophysiological relevance and their regulation in oxidative stress-related conditions.https://www.mdpi.com/2073-4409/13/23/2026erythrocytesredox systemintracellular pathwaysmetabolismantioxidant machinery |
| spellingShingle | Sara Spinelli Angela Marino Rossana Morabito Alessia Remigante Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood Cells Cells erythrocytes redox system intracellular pathways metabolism antioxidant machinery |
| title | Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood Cells |
| title_full | Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood Cells |
| title_fullStr | Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood Cells |
| title_full_unstemmed | Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood Cells |
| title_short | Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood Cells |
| title_sort | interplay between metabolic pathways and increased oxidative stress in human red blood cells |
| topic | erythrocytes redox system intracellular pathways metabolism antioxidant machinery |
| url | https://www.mdpi.com/2073-4409/13/23/2026 |
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