Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma
Childhood trauma (CT) often co-occurs with alcohol use disorder (AUD) and is associated with poor treatment outcome. We could demonstrated that patients with AUD and a history of childhood trauma showed reduced structural connectivity of the amygdala. Here, we additionally aimed to investigate front...
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Elsevier
2024-12-01
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| Series: | NeuroImage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956024000291 |
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| author | Elisabeth Jehli Fabienne Burri Niklaus Denier Franz Moggi Andrea Federspiel Roland Wiest Maria Stein Tobias Bracht Matthias Grieder Leila M. Soravia |
| author_facet | Elisabeth Jehli Fabienne Burri Niklaus Denier Franz Moggi Andrea Federspiel Roland Wiest Maria Stein Tobias Bracht Matthias Grieder Leila M. Soravia |
| author_sort | Elisabeth Jehli |
| collection | DOAJ |
| description | Childhood trauma (CT) often co-occurs with alcohol use disorder (AUD) and is associated with poor treatment outcome. We could demonstrated that patients with AUD and a history of childhood trauma showed reduced structural connectivity of the amygdala. Here, we additionally aimed to investigate fronto-limbic functional connectivity (FC) in patients with AUD with (AUD-CT) and without (AUD-noCT) CT. Based on findings in CT, we hypothesized reduced FC of the amygdala with the prefrontal cortex in AUD-CT and worse treatment outcome compared to AUD-noCT.Resting state fMRI scans were acquired in abstinent inpatients with AUD and healthy controls (HCs). We compared bilateral amygdala FC between AUD-CT (n = 21), AUD-noCT (n = 22), and HC (n = 27) using seed-based connectivity (SBC) and region-of-interest to region-of-interest (ROI-ROI) analysis. Sociodemographic and alcohol-specific variables (percent days abstinent, PDA) were assessed at treatment admission and three-month follow-up. The Childhood Trauma Questionnaire (CTQ) assessed trauma severity. SBC analysis revealed that AUD-CT showed increased FC of the left and right amygdala with the medial prefrontal cortex and left paracingulate gyrus compared to HC. AUD-CT showed increased ROI-ROI FC of the left with the right amygdala and the right amygdala with the medial prefrontal cortex. Moreover, AUD-CT exhibited a greater reduction of PDA at three-month follow-up compared to AUD-noCT.Increased FC of the amygdala, the medial prefrontal cortex, and paracingulate gyrus in AUD-CT might be a compensatory adaption to the reduced structural connectivity of the amygdala. Those specific alterations of FC in AUD-CT may represent a distinguishable neurobiological subtype of AUD, possibly underlying the complex clinical picture and worse treatment outcome. |
| format | Article |
| id | doaj-art-534dd9e33df74e7195ebefb173127549 |
| institution | OA Journals |
| issn | 2666-9560 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Reports |
| spelling | doaj-art-534dd9e33df74e7195ebefb1731275492025-08-20T01:56:28ZengElsevierNeuroImage: Reports2666-95602024-12-014410022310.1016/j.ynirp.2024.100223Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood traumaElisabeth Jehli0Fabienne Burri1Niklaus Denier2Franz Moggi3Andrea Federspiel4Roland Wiest5Maria Stein6Tobias Bracht7Matthias Grieder8Leila M. Soravia9Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; University Hospital of Zurich, Department of Neurosurgery, Zurich, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandInstitute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Department of Clinical Psychology and Psychotherapy, Institute of Psychology, University of Bern, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Clinic Suedhang, Kirchlindach, Switzerland; Corresponding author. University Hospital of Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111, 3000, Bern, 60, Switzerland.Childhood trauma (CT) often co-occurs with alcohol use disorder (AUD) and is associated with poor treatment outcome. We could demonstrated that patients with AUD and a history of childhood trauma showed reduced structural connectivity of the amygdala. Here, we additionally aimed to investigate fronto-limbic functional connectivity (FC) in patients with AUD with (AUD-CT) and without (AUD-noCT) CT. Based on findings in CT, we hypothesized reduced FC of the amygdala with the prefrontal cortex in AUD-CT and worse treatment outcome compared to AUD-noCT.Resting state fMRI scans were acquired in abstinent inpatients with AUD and healthy controls (HCs). We compared bilateral amygdala FC between AUD-CT (n = 21), AUD-noCT (n = 22), and HC (n = 27) using seed-based connectivity (SBC) and region-of-interest to region-of-interest (ROI-ROI) analysis. Sociodemographic and alcohol-specific variables (percent days abstinent, PDA) were assessed at treatment admission and three-month follow-up. The Childhood Trauma Questionnaire (CTQ) assessed trauma severity. SBC analysis revealed that AUD-CT showed increased FC of the left and right amygdala with the medial prefrontal cortex and left paracingulate gyrus compared to HC. AUD-CT showed increased ROI-ROI FC of the left with the right amygdala and the right amygdala with the medial prefrontal cortex. Moreover, AUD-CT exhibited a greater reduction of PDA at three-month follow-up compared to AUD-noCT.Increased FC of the amygdala, the medial prefrontal cortex, and paracingulate gyrus in AUD-CT might be a compensatory adaption to the reduced structural connectivity of the amygdala. Those specific alterations of FC in AUD-CT may represent a distinguishable neurobiological subtype of AUD, possibly underlying the complex clinical picture and worse treatment outcome.http://www.sciencedirect.com/science/article/pii/S2666956024000291Alcohol use disorderAmygdalaChildhood traumaFunctional connectivityResting state fMRI |
| spellingShingle | Elisabeth Jehli Fabienne Burri Niklaus Denier Franz Moggi Andrea Federspiel Roland Wiest Maria Stein Tobias Bracht Matthias Grieder Leila M. Soravia Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma NeuroImage: Reports Alcohol use disorder Amygdala Childhood trauma Functional connectivity Resting state fMRI |
| title | Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma |
| title_full | Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma |
| title_fullStr | Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma |
| title_full_unstemmed | Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma |
| title_short | Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma |
| title_sort | increased functional connectivity of amygdalar frontal pathways in patients with alcohol use disorder and childhood trauma |
| topic | Alcohol use disorder Amygdala Childhood trauma Functional connectivity Resting state fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S2666956024000291 |
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