The Integral Role and Clinical Significance of Metabolic Profiling in Prostate Cancer: A Narrative Review
Prostate cancer (PC) is the most commonly diagnosed malignancy among males worldwide. In recent years, there has been a need to find alternative methods for the early diagnosis of PC. Evidence indicates that metabolic dysfunction is a characteristic feature of PC carcinogenesis, with various metabol...
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| Format: | Article |
| Language: | English |
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Korean Urological Oncology Society
2024-07-01
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| Series: | Journal of Urologic Oncology |
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| Online Access: | http://www.e-juo.org/upload/pdf/juo-244800260013.pdf |
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| author | Valentin Nikolaevich Pavlov Marat Fayazovich Urmantsev Marat Radikovich Bakeev Olalekan Samuel Akinyemi |
| author_facet | Valentin Nikolaevich Pavlov Marat Fayazovich Urmantsev Marat Radikovich Bakeev Olalekan Samuel Akinyemi |
| author_sort | Valentin Nikolaevich Pavlov |
| collection | DOAJ |
| description | Prostate cancer (PC) is the most commonly diagnosed malignancy among males worldwide. In recent years, there has been a need to find alternative methods for the early diagnosis of PC. Evidence indicates that metabolic dysfunction is a characteristic feature of PC carcinogenesis, with various metabolites acting as biomarkers of tumor growth. Metabolomics is a new science that has emerged at the intersection of molecular biology, biochemistry, and genetics. The complete set of substrates and metabolic products is a metabolic profile, or metabolome. The PC metabolome comprises substances formed as a result of metabolic changes in response to the occurrence of a malignant process in the prostate gland. We have obtained unique data on metabolic changes that allow us to rethink the carcinogenesis of PC. Research on the metabolome opens up new opportunities for the early diagnosis and treatment of PC, with implications for its prognosis. |
| format | Article |
| id | doaj-art-534bc8a3e75043d8a626ce540785cc44 |
| institution | OA Journals |
| issn | 2951-603X 2982-7043 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Korean Urological Oncology Society |
| record_format | Article |
| series | Journal of Urologic Oncology |
| spelling | doaj-art-534bc8a3e75043d8a626ce540785cc442025-08-20T02:38:29ZengKorean Urological Oncology SocietyJournal of Urologic Oncology2951-603X2982-70432024-07-0122215015610.22465/juo.244800260013584The Integral Role and Clinical Significance of Metabolic Profiling in Prostate Cancer: A Narrative ReviewValentin Nikolaevich Pavlov0Marat Fayazovich Urmantsev1Marat Radikovich Bakeev2Olalekan Samuel Akinyemi3 Department of Urology, Bashkir State Medical University, Ufa, Russia Department of Urology, Bashkir State Medical University, Ufa, Russia Department of Urology, Bashkir State Medical University, Ufa, Russia Department of Urology, Bashkir State Medical University, Ufa, RussiaProstate cancer (PC) is the most commonly diagnosed malignancy among males worldwide. In recent years, there has been a need to find alternative methods for the early diagnosis of PC. Evidence indicates that metabolic dysfunction is a characteristic feature of PC carcinogenesis, with various metabolites acting as biomarkers of tumor growth. Metabolomics is a new science that has emerged at the intersection of molecular biology, biochemistry, and genetics. The complete set of substrates and metabolic products is a metabolic profile, or metabolome. The PC metabolome comprises substances formed as a result of metabolic changes in response to the occurrence of a malignant process in the prostate gland. We have obtained unique data on metabolic changes that allow us to rethink the carcinogenesis of PC. Research on the metabolome opens up new opportunities for the early diagnosis and treatment of PC, with implications for its prognosis.http://www.e-juo.org/upload/pdf/juo-244800260013.pdfprostatic neoplasmsmetabolomicsmetabolomebiomarkersprostatic hyperplasia |
| spellingShingle | Valentin Nikolaevich Pavlov Marat Fayazovich Urmantsev Marat Radikovich Bakeev Olalekan Samuel Akinyemi The Integral Role and Clinical Significance of Metabolic Profiling in Prostate Cancer: A Narrative Review Journal of Urologic Oncology prostatic neoplasms metabolomics metabolome biomarkers prostatic hyperplasia |
| title | The Integral Role and Clinical Significance of Metabolic Profiling in Prostate Cancer: A Narrative Review |
| title_full | The Integral Role and Clinical Significance of Metabolic Profiling in Prostate Cancer: A Narrative Review |
| title_fullStr | The Integral Role and Clinical Significance of Metabolic Profiling in Prostate Cancer: A Narrative Review |
| title_full_unstemmed | The Integral Role and Clinical Significance of Metabolic Profiling in Prostate Cancer: A Narrative Review |
| title_short | The Integral Role and Clinical Significance of Metabolic Profiling in Prostate Cancer: A Narrative Review |
| title_sort | integral role and clinical significance of metabolic profiling in prostate cancer a narrative review |
| topic | prostatic neoplasms metabolomics metabolome biomarkers prostatic hyperplasia |
| url | http://www.e-juo.org/upload/pdf/juo-244800260013.pdf |
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